Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish

The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in the human STUB1 gene are associated with recessive and dominant forms of spinoc...

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Detalles Bibliográficos
Autores principales: Pakdaman, Yasaman, Denker, Elsa, Austad, Eirik, Norton, William H. J., Rolfsnes, Hans O., Bindoff, Laurence A., Tzoulis, Charalampos, Aukrust, Ingvild, Knappskog, Per M., Johansson, Stefan, Ellingsen, Ståle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497888/
https://www.ncbi.nlm.nih.gov/pubmed/34630034
http://dx.doi.org/10.3389/fnmol.2021.723912

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