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Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations

Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria occur in several neurodegenerative diseases. Previously, we showed mitochon...

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Detalles Bibliográficos
Autores principales:	Chen, Anbin, Kristiansen, Cecilie Katrin, Hong, Yu, Kianian, Atefeh, Fang, Evandro Fei, Sullivan, Gareth John, Wang, Jian, Li, Xingang, Bindoff, Laurence A., Liang, Kristina Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497894/ https://www.ncbi.nlm.nih.gov/pubmed/34631714 http://dx.doi.org/10.3389/fcell.2021.737304

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