Cargando…

Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters

BACKGROUND: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting diagnosis and treatment of head and neck squamous cell carcinomas (HNSCC) is stil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dongre, Harsh N., Haave, Hilde, Fromreide, Siren, Erland, Fredrik A., Moe, Svein Erik Emblem, Dhayalan, Sophia Manueldas, Riis, Rasmus Kopperud, Sapkota, Dipak, Costea, Daniela Elena, Aarstad, Hans Jorgen, Vintermyr, Olav K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497964/ https://www.ncbi.nlm.nih.gov/pubmed/34631566 http://dx.doi.org/10.3389/fonc.2021.734134

Ejemplares similares

The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients
por: Moe, Svein Erik, et al.
Publicado: (2023)

Tumor Infiltration Levels of CD3, Foxp3 (+) Lymphocytes and CD68 Macrophages at Diagnosis Predict 5-Year Disease-Specific Survival in Patients with Oropharynx Squamous Cell Carcinoma
por: Ljokjel, Borghild, et al.
Publicado: (2022)

Tumor HPV Status, Level of Regulatory T Cells and Macrophage Infiltration Predict up to 20-Year Non-Disease-Specific Survival in Oropharynx Squamous Cell Carcinoma Patients
por: Haave, Hilde, et al.
Publicado: (2022)

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles
por: Aarstad, Helene Hersvik, et al.
Publicado: (2020)

In Vitro-Stimulated IL-6 Monocyte Secretion and In Vivo Peripheral Blood T Lymphocyte Activation Uniquely Predicted 15-Year Survival in Patients with Head and Neck Squamous Cell Carcinoma
por: Aarstad, Helene Hersvik, et al.
Publicado: (2015)

Epithelial PD‐L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan
por: Gaafar, Nuha M., et al.
Publicado: (2022)

Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients
por: Gaafar, Nuha Mohamed, et al.
Publicado: (2021)

Combined In Situ Hybridization and Immunohistochemistry on Archival Tissues Reveals Stromal microRNA-204 as Prognostic Biomarker for Oral Squamous Cell Carcinoma
por: Rajthala, Saroj, et al.
Publicado: (2021)

Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients
por: Pandey, Sushma, et al.
Publicado: (2020)

The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas
por: Søland, Tine M., et al.
Publicado: (2022)

MicroRNA-138 Abates Fibroblast Motility With Effect on Invasion of Adjacent Cancer Cells
por: Rajthala, Saroj, et al.
Publicado: (2022)

Profiling and Functional Analysis of microRNA Deregulation in Cancer-Associated Fibroblasts in Oral Squamous Cell Carcinoma Depicts an Anti-Invasive Role of microRNA-204 via Regulation of Their Motility
por: Rajthala, Saroj, et al.
Publicado: (2021)

The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination
por: Kråkenes, Torbjørn, et al.
Publicado: (2023)

Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
por: Bredholt, Therese, et al.
Publicado: (2013)

Treatment decisions on Molar-Incisor Hypomineralization (MIH) by Norwegian dentists – a questionnaire study
por: Kopperud, Simen E., et al.
Publicado: (2016)

Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children
por: Rajalahti, Tarja, et al.
Publicado: (2016)

Patient satisfaction with conventional, complementary, and alternative treatment for cluster headache in a Norwegian cohort
por: Bekkelund, Svein I., et al.
Publicado: (2014)

Expression profile and functional role of S100A14 in human cancer
por: Basnet, Suyog, et al.
Publicado: (2019)

Associations between the time of conception and the shape of the lactation curve in early lactation in Norwegian dairy cattle
por: Andersen, Fredrik, et al.
Publicado: (2011)

Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health
por: Lin, Chenchen, et al.
Publicado: (2015)

The Post-Amalgam Era: Norwegian Dentists’ Experiences with Composite Resins and Repair of Defective Amalgam Restorations
por: Kopperud, Simen E., et al.
Publicado: (2016)

Molecular Epidemiology of the Norwegian SARS-CoV-2 Delta Lineage AY.63
por: Moen, Line Victoria, et al.
Publicado: (2022)

Treating equivalent cases differently: A comparative analysis of substance use disorder and type 2 diabetes in Norwegian treatment guidelines
por: Moe, Fredrik D., et al.
Publicado: (2022)

Ongoing recruitment crisis In Norwegian general practice
por: Kjosavik, Svein R.
Publicado: (2018)

Opinions on Dental Erosive Lesions, Knowledge of Diagnosis, and Treatment Strategies among Norwegian Dentists: A Questionnaire Survey
por: Mulic, Aida, et al.
Publicado: (2012)

Do New Firms Recruit Employees From Small or Large Firms, and Do Small or Large Firms Recruit Employees From Firms That Cease to Operate?
por: Aarstad, Jarle, et al.
Publicado: (2022)

MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis
por: Min, Anjie, et al.
Publicado: (2015)

S100A14 Interacts with S100A16 and Regulates Its Expression in Human Cancer Cells
por: Sapkota, Dipak, et al.
Publicado: (2013)

Family satisfaction in the intensive care unit, a cross-sectional study from Norway
por: Haave, Randi Olsson, et al.
Publicado: (2021)

High‐risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue
por: Søland, Tine M., et al.
Publicado: (2020)

Hearing loss in Norwegian adults with achondroplasia
por: Fredwall, Svein O., et al.
Publicado: (2021)

Belly flap from Norwegian spring-spawning herring (Clupea harengus L.): A potentially new product with high content of vitamin D, EPA and DHA
por: Kjerstad, Margareth, et al.
Publicado: (2020)

Resilience and Poly-Victimization among Two Cohorts of Norwegian Youth
por: Huang, Lihong, et al.
Publicado: (2018)

The burden of hospital-attended influenza in Norwegian children
por: Bøås, Håkon, et al.
Publicado: (2022)

Residents’ perceptions of their own sadness - a qualitative study in Norwegian nursing homes
por: Iden, Kristina Riis, et al.
Publicado: (2015)

Match Running Performance on Three Different Competitive Standards in Norwegian Soccer
por: Sæterbakken, Atle, et al.
Publicado: (2019)

Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands
por: Bharaj, Tamandeep K., et al.
Publicado: (2021)

Physical fitness and activity level in Norwegian adults with achondroplasia
por: de Vries, Olga Marieke, et al.
Publicado: (2020)

Drink reception for the Norwegian CERN community
por: Mo, Jorgen Andreas
Publicado: (2019)

R&D investments and employment decisions as a function of enterprise size and regional population density before and during COVID-19
por: Aarstad, Jarle, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lfi0r0j4ao1tqkfiulgedergrc