α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants

The increase in confirmed COVID-19 cases and SARS-CoV-2 variants calls for the development of safe and broad cross-protective vaccines. The RBD of the spike protein was considered to be a safe and effective candidate antigen. However, the low immunogenicity limited its application in vaccine develop...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Jintao, Jing, Haiming, Zhang, Xiaoli, Liu, Yiheng, Zhao, Zhuo, Duan, Lianli, Yuan, Yue, Chen, Zhifu, Gou, Qiang, Xiong, Qingshan, Li, Sisi, Yang, Feng, Zeng, Hao, Zou, Quanming, Zhang, Jinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497984/
https://www.ncbi.nlm.nih.gov/pubmed/34630436
http://dx.doi.org/10.3389/fimmu.2021.757691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497984/
https://www.ncbi.nlm.nih.gov/pubmed/34630436
http://dx.doi.org/10.3389/fimmu.2021.757691

Ejemplares similares