Cargando…

α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants

The increase in confirmed COVID-19 cases and SARS-CoV-2 variants calls for the development of safe and broad cross-protective vaccines. The RBD of the spike protein was considered to be a safe and effective candidate antigen. However, the low immunogenicity limited its application in vaccine develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Jintao, Jing, Haiming, Zhang, Xiaoli, Liu, Yiheng, Zhao, Zhuo, Duan, Lianli, Yuan, Yue, Chen, Zhifu, Gou, Qiang, Xiong, Qingshan, Li, Sisi, Yang, Feng, Zeng, Hao, Zou, Quanming, Zhang, Jinyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497984/ https://www.ncbi.nlm.nih.gov/pubmed/34630436 http://dx.doi.org/10.3389/fimmu.2021.757691

Ejemplares similares

Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia
por: Chen, Zhifu, et al.
Publicado: (2021)

Genome Sequence of Klebsiella pneumoniae YBQ, a Clinical Strain Isolated from the Sputum of a Patient with Severe Pneumonia
por: Zou, Jintao, et al.
Publicado: (2020)

Antibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection
por: Duan, LianLi, et al.
Publicado: (2021)

Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae
por: Liu, Dong, et al.
Publicado: (2020)

Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens
por: Zou, Jin-Tao, et al.
Publicado: (2021)

PA0833 Is an OmpA C-Like Protein That Confers Protection Against Pseudomonas aeruginosa Infection
por: Yang, Feng, et al.
Publicado: (2018)

Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2
por: Passariello, Margherita, et al.
Publicado: (2021)

Host Immune Response to Clinical Hypervirulent Klebsiella pneumoniae Pulmonary Infections via Transcriptome Analysis
por: Lei, Langhuan, et al.
Publicado: (2022)

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice
por: Mabrouk, Moustafa T., et al.
Publicado: (2021)

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein
por: Otsubo, Ryota, et al.
Publicado: (2022)

Protective Efficacy and Mechanism of Passive Immunization with Polyclonal Antibodies in a Sepsis Model of Staphylococcus aureus Infection
por: Zhang, Jinyong, et al.
Publicado: (2015)

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
por: Huo, Jiangdong, et al.
Publicado: (2020)

Dynamic Assay for Profiling Anti-SARS-CoV-2 Antibodies and Their ACE2/Spike RBD Neutralization Capacity
por: Phelan, Thomas, et al.
Publicado: (2021)

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
por: Huo, Jiandong, et al.
Publicado: (2021)

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
por: Chen, Yaozong, et al.
Publicado: (2022)

Baculovirus displaying SARS-CoV-2 spike RBD promotes neutralizing antibody production in a mouse model
por: Wahba, Mohamed A., et al.
Publicado: (2023)

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
por: Sun, Shiyu, et al.
Publicado: (2021)

Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5
por: Shi, Deling, et al.
Publicado: (2022)

Immunodominant antigens that induce Th1 and Th17 responses protect mice against Helicobacter pylori infection
por: Sun, Heqiang, et al.
Publicado: (2018)

Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1
por: Yang, Ge, et al.
Publicado: (2021)

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum
por: Lu, Lu, et al.
Publicado: (2021)

Biomimetic Nanosponges Enable the Detoxification of Vibrio vulnificus Hemolysin
por: Zou, Shuaijun, et al.
Publicado: (2022)

Author Correction: Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
por: Sun, Shiyu, et al.
Publicado: (2021)

THE PRECISE MEASUREMENT OF HEMOLYSIN
por: Coulter, Calvin B.
Publicado: (1927)

HEMOLYSINS OF VEGETABLE ORIGIN
por: Kritchevsky, I. L.
Publicado: (1917)

ANTIGENIC STREPTOCOCCAL HEMOLYSIN
por: Todd, E. W.
Publicado: (1932)

Glycosylation and oligomerization of the spike protein of marburg virus
por: Feldmann, H., et al.
Publicado: (1991)

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants
por: Lin, Wei-Shuo, et al.
Publicado: (2021)

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants
por: Rodriguez-Aponte, Sergio A., et al.
Publicado: (2023)

Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine
por: Li, Chia-Jung, et al.
Publicado: (2023)

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding
por: Lin, Sheng, et al.
Publicado: (2022)

Comparative Analysis of a Human Neutralizing mAb Specific for SARS-CoV-2 Spike-RBD with Cilgavimab and Tixagevimab for the Efficacy on the Omicron Variant in Neutralizing and Detection Assays
por: Passariello, Margherita, et al.
Publicado: (2023)

Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus
por: Raghunath, Pendru
Publicado: (2015)

An Algae-Made RBD from SARS-CoV-2 Is Immunogenic in Mice
por: Govea-Alonso, Dania O., et al.
Publicado: (2022)

Dual-detection fluorescent immunochromatographic assay for quantitative detection of SARS-CoV-2 spike RBD-ACE2 blocking neutralizing antibody
por: Duan, Xuejun, et al.
Publicado: (2022)

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
por: Song, Ge, et al.
Publicado: (2023)

Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4
por: He, Jintao, et al.
Publicado: (2022)

ELECTRIC CHARGES CARRIED BY THE HEMOLYSINS
por: Teague, Oscar, et al.
Publicado: (1907)

Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
por: Yang, Feng, et al.
Publicado: (2017)

OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCOCCI : III. THE RELATIONSHIP OF THE CELL-BOUND HEMOLYSIN TO STREPTOLYSIN S
por: Ginsburg, Isaac, et al.
Publicado: (1965)

Cannot write session to /tmp/vufind_sessions/sess_l4vsmedtr58sgq141carg57u3t