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Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins

Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP triphosphohydrolase (dNTPase), sterile alpha motif and histidine–aspartate domain–containing protein 1 (SAMHD1), have been reported in variou...

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Detalles Bibliográficos
Autores principales:	Bowen, Nicole E., Temple, Joshua, Shepard, Caitlin, Oo, Adrian, Arizaga, Fidel, Kapoor-Vazirani, Priya, Persaud, Mirjana, Yu, Corey H., Kim, Dong-Hyun, Schinazi, Raymond F., Ivanov, Dmitri N., Diaz-Griffero, Felipe, Yu, David S., Xiong, Yong, Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497992/ https://www.ncbi.nlm.nih.gov/pubmed/34492268 http://dx.doi.org/10.1016/j.jbc.2021.101170

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