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Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance
BACKGROUND & AIMS: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubin has antioxidant and anti-inflammatory activi...
Autores principales: | Chen, Weiyu, Tumanov, Sergey, Fazarkeley, Daniel, Cantley, James, James, David E., Dunn, Louise L., Shaik, Taqi, Suarna, Cacang, Stocker, Roland |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498001/ https://www.ncbi.nlm.nih.gov/pubmed/34610553 http://dx.doi.org/10.1016/j.redox.2021.102152 |
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