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Obesity and chronic kidney disease: prevalence, mechanism, and management
The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Pediatric Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498012/ https://www.ncbi.nlm.nih.gov/pubmed/33831296 http://dx.doi.org/10.3345/cep.2021.00108 |
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author | Yim, Hyung Eun Yoo, Kee Hwan |
author_facet | Yim, Hyung Eun Yoo, Kee Hwan |
author_sort | Yim, Hyung Eun |
collection | PubMed |
description | The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression. |
format | Online Article Text |
id | pubmed-8498012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84980122021-10-19 Obesity and chronic kidney disease: prevalence, mechanism, and management Yim, Hyung Eun Yoo, Kee Hwan Clin Exp Pediatr Review Article The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression. Korean Pediatric Society 2021-04-06 /pmc/articles/PMC8498012/ /pubmed/33831296 http://dx.doi.org/10.3345/cep.2021.00108 Text en Copyright © 2021 by The Korean Pediatric Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yim, Hyung Eun Yoo, Kee Hwan Obesity and chronic kidney disease: prevalence, mechanism, and management |
title | Obesity and chronic kidney disease: prevalence, mechanism, and management |
title_full | Obesity and chronic kidney disease: prevalence, mechanism, and management |
title_fullStr | Obesity and chronic kidney disease: prevalence, mechanism, and management |
title_full_unstemmed | Obesity and chronic kidney disease: prevalence, mechanism, and management |
title_short | Obesity and chronic kidney disease: prevalence, mechanism, and management |
title_sort | obesity and chronic kidney disease: prevalence, mechanism, and management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498012/ https://www.ncbi.nlm.nih.gov/pubmed/33831296 http://dx.doi.org/10.3345/cep.2021.00108 |
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