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Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice

The gut microbiota is closely associated with the health of the host and is affected by many factors, including exercise. In this study, we compared the gut microbial changes and exercise performance over a 14-week period in mice that performed exercise (NE; n = 15) and mice that did not perform exe...

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Autores principales: Yang, Wenqian, Liu, Yuqian, Yang, Guang, Meng, Binglin, Yi, Zhicheng, Yang, Guan, Chen, Mingjian, Hou, Pengcheng, Wang, Haitao, Xu, Xiaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498591/
https://www.ncbi.nlm.nih.gov/pubmed/34631598
http://dx.doi.org/10.3389/fcimb.2021.712381
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author Yang, Wenqian
Liu, Yuqian
Yang, Guang
Meng, Binglin
Yi, Zhicheng
Yang, Guan
Chen, Mingjian
Hou, Pengcheng
Wang, Haitao
Xu, Xiaoyang
author_facet Yang, Wenqian
Liu, Yuqian
Yang, Guang
Meng, Binglin
Yi, Zhicheng
Yang, Guan
Chen, Mingjian
Hou, Pengcheng
Wang, Haitao
Xu, Xiaoyang
author_sort Yang, Wenqian
collection PubMed
description The gut microbiota is closely associated with the health of the host and is affected by many factors, including exercise. In this study, we compared the gut microbial changes and exercise performance over a 14-week period in mice that performed exercise (NE; n = 15) and mice that did not perform exercise (NC; n = 15). Mice were subjected to stool collection and exercise tests one week prior to adaptive training and after 2, 6, 10, and 14 weeks of exercise. Bacteria associated with the stool samples were assessed via Illumina-based 16S rRNA gene sequencing. While there was no significant difference in body weight between the groups (p > 0.05), the NE group had a significantly higher exercise performance from weeks 2–14 (p < 0.01) and lower fat coefficient (p < 0.01) compared with the NC group. The Shannon index of the gut microbiota in the NC group was higher than that in the NE group at weeks 6 and 10, and the Chao1 index was higher than that in the NE group at week 14. Exercise performance positively correlated with the relative abundance of Phascolarctobacterium. Grouped time series data analysis demonstrated that Bifidobacteria, Coprococcus, and one unnamed genus in the Clostridiales order were significantly increased in the NE group, which correlated with increased glucose, flavonoid, arginine, and proline metabolism. In conclusion, moderate-intensity treadmill exercise significantly increased the exercise performance of mice and changed the core bacteria and bacterial metabolic activity. These results provide a reference for studying the effects of exercise intervention and exercise performance on the gut microbiota of mice.
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spelling pubmed-84985912021-10-09 Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice Yang, Wenqian Liu, Yuqian Yang, Guang Meng, Binglin Yi, Zhicheng Yang, Guan Chen, Mingjian Hou, Pengcheng Wang, Haitao Xu, Xiaoyang Front Cell Infect Microbiol Cellular and Infection Microbiology The gut microbiota is closely associated with the health of the host and is affected by many factors, including exercise. In this study, we compared the gut microbial changes and exercise performance over a 14-week period in mice that performed exercise (NE; n = 15) and mice that did not perform exercise (NC; n = 15). Mice were subjected to stool collection and exercise tests one week prior to adaptive training and after 2, 6, 10, and 14 weeks of exercise. Bacteria associated with the stool samples were assessed via Illumina-based 16S rRNA gene sequencing. While there was no significant difference in body weight between the groups (p > 0.05), the NE group had a significantly higher exercise performance from weeks 2–14 (p < 0.01) and lower fat coefficient (p < 0.01) compared with the NC group. The Shannon index of the gut microbiota in the NC group was higher than that in the NE group at weeks 6 and 10, and the Chao1 index was higher than that in the NE group at week 14. Exercise performance positively correlated with the relative abundance of Phascolarctobacterium. Grouped time series data analysis demonstrated that Bifidobacteria, Coprococcus, and one unnamed genus in the Clostridiales order were significantly increased in the NE group, which correlated with increased glucose, flavonoid, arginine, and proline metabolism. In conclusion, moderate-intensity treadmill exercise significantly increased the exercise performance of mice and changed the core bacteria and bacterial metabolic activity. These results provide a reference for studying the effects of exercise intervention and exercise performance on the gut microbiota of mice. Frontiers Media S.A. 2021-09-24 /pmc/articles/PMC8498591/ /pubmed/34631598 http://dx.doi.org/10.3389/fcimb.2021.712381 Text en Copyright © 2021 Yang, Liu, Yang, Meng, Yi, Yang, Chen, Hou, Wang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Yang, Wenqian
Liu, Yuqian
Yang, Guang
Meng, Binglin
Yi, Zhicheng
Yang, Guan
Chen, Mingjian
Hou, Pengcheng
Wang, Haitao
Xu, Xiaoyang
Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title_full Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title_fullStr Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title_full_unstemmed Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title_short Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice
title_sort moderate-intensity physical exercise affects the exercise performance and gut microbiota of mice
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498591/
https://www.ncbi.nlm.nih.gov/pubmed/34631598
http://dx.doi.org/10.3389/fcimb.2021.712381
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