Cargando…

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has necessitated the rapid development of antibody-based therapies and vaccines as countermeasures. Here, we use cryoelectron microscopy (cryo-EM) to characterize two protective anti-SARS-CoV-2 murine monoclonal antibodies (mA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Errico, John M., Zhao, Haiyan, Chen, Rita E., Liu, Zhuoming, Case, James Brett, Ma, Meisheng, Schmitz, Aaron J., Rau, Michael J., Fitzpatrick, James A.J., Shi, Pei-Yong, Diamond, Michael S., Whelan, Sean P.J., Ellebedy, Ali H., Fremont, Daved H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Author(s). 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498651/ https://www.ncbi.nlm.nih.gov/pubmed/34655519 http://dx.doi.org/10.1016/j.celrep.2021.109881

Ejemplares similares

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
por: Liu, Zhuoming, et al.
Publicado: (2021)

The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies
por: Earnest, James T., et al.
Publicado: (2021)

Detection of Bourbon Virus-Specific Serum Neutralizing Antibodies in Human Serum in Missouri, USA
por: Bamunuarachchi, Gayan, et al.
Publicado: (2022)

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2
por: Case, James Brett, et al.
Publicado: (2020)

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice
por: Case, James Brett, et al.
Publicado: (2020)

Structural basis of West Nile virus neutralization by a therapeutic antibody
por: Nybakken, Grant E., et al.
Publicado: (2005)

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
por: VanBlargan, Laura A., et al.
Publicado: (2021)

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies
por: VanBlargan, Laura, et al.
Publicado: (2021)

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
por: Hassan, Ahmed O., et al.
Publicado: (2020)

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies
por: VanBlargan, Laura A., et al.
Publicado: (2022)

Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge
por: Zhao, Haiyan, et al.
Publicado: (2019)

Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity
por: Earnest, James T., et al.
Publicado: (2019)

A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes
por: Thompson, Bruce S., et al.
Publicado: (2009)

Antibody-mediated immunity to SARS-CoV-2 spike
por: Errico, John M., et al.
Publicado: (2022)

SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies
por: Diamond, Michael, et al.
Publicado: (2021)

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis
por: Case, James Brett, et al.
Publicado: (2020)

A molecular understanding of alphavirus entry
por: Holmes, Autumn C., et al.
Publicado: (2020)

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope
por: Austin, S. Kyle, et al.
Publicado: (2012)

Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination
por: Han, Julianna, et al.
Publicado: (2021)

The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1
por: Shrestha, Bimmi, et al.
Publicado: (2010)

Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor
por: Alexander-Brett, Jennifer M., et al.
Publicado: (2007)

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains
por: Diamond, Michael, et al.
Publicado: (2021)

On the road to ending the COVID-19 pandemic: Are we there yet?
por: Case, James Brett, et al.
Publicado: (2021)

Structure and Intracellular Targeting of the SARS-Coronavirus Orf7a Accessory Protein
por: Nelson, Christopher A., et al.
Publicado: (2005)

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters
por: Bricker, Traci L., et al.
Publicado: (2021)

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses
por: Tai, Wanbo, et al.
Publicado: (2018)

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
por: Zang, Ruochen, et al.
Publicado: (2020)

The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD
por: Amanat, Fatima, et al.
Publicado: (2021)

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
por: Ma, Hongming, et al.
Publicado: (2020)

Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses
por: VanBlargan, Laura A., et al.
Publicado: (2021)

Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b
por: Pekosz, Andrew, et al.
Publicado: (2006)

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants
por: Schmitz, Aaron J., et al.
Publicado: (2021)

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy
por: Hassan, Ahmed O., et al.
Publicado: (2019)

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
por: Hassan, Ahmed O., et al.
Publicado: (2021)

The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD
por: Greaney, Allison J., et al.
Publicado: (2021)

Capturing a Flavivirus Pre-Fusion Intermediate
por: Kaufmann, Bärbel, et al.
Publicado: (2009)

Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus
por: Doyle, Michael P., et al.
Publicado: (2022)

Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement
por: Edeling, Melissa A., et al.
Publicado: (2014)

Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines
por: Dickey, Thayne H., et al.
Publicado: (2023)

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
por: Deshpande, Ashlesha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jnr8njl3bq3cqrkb3qn4dtduh3