Anti-glomerular basement membrane disease with intense nephrotic syndrome: a new case report

Anti-glomerular basement membrane (anti-GBM) disease was usually described as a small vessel vasculitis presenting with acute kidney injury, haematuria and non-nephrotic proteinuria. We report a case of anti-GBM disease revealed by an intense nephrotic syndrome. The urinary protein level was 12g/day...

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Detalles Bibliográficos
Autores principales: Mami, Ikram, Ghzel, Emna, Abida, Rym, Hlaoui, Fadwa, Jebali, Hela, Rais, Lamia, Beji, Soumaya, Hamida, Fethi Ben, Fatma, Lilia Ben, Zouaghi, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498661/
https://www.ncbi.nlm.nih.gov/pubmed/34659616
http://dx.doi.org/10.11604/pamj.2021.39.243.30461
Descripción
Sumario:Anti-glomerular basement membrane (anti-GBM) disease was usually described as a small vessel vasculitis presenting with acute kidney injury, haematuria and non-nephrotic proteinuria. We report a case of anti-GBM disease revealed by an intense nephrotic syndrome. The urinary protein level was 12g/day. Renal biopsy only showed crescent glomerulonephritis with linear staining of IgG in direct immunofluorescence without other glomerulonephritis. Immunoglobulin G (IgG) anti-GBM antibody titer was elevated.

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