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Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy

Rhabdomyosarcoma (RMS) is an aggressive type of soft tissue sarcoma, and pleomorphic RMS is a rare subtype of RMS found in adult. p16 is a tumor suppressor which inhibits cell cycle. In human RMS, p16 gene is frequently deleted, but p16-null mice do not develop RMS. We reported that genetic ablation...

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Detalles Bibliográficos
Autores principales:	TERAMOTO, Naomi, IKEDA, Masanari, SUGIHARA, Hidetoshi, SHIGA, Takanori, MATSUWAKI, Takashi, NISHIHARA, Masugi, UCHIDA, Kazuyuki, YAMANOUCHI, Keitaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Japanese Society of Veterinary Science 2021
Materias:	Laboratory Animal Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498826/ https://www.ncbi.nlm.nih.gov/pubmed/34334511 http://dx.doi.org/10.1292/jvms.21-0243

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