Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy

We determined a comprehensive immunohistochemistry of putative isoforms of enzymes for prostaglandin (PG) F(2)α and PGE(2) biosynthesis and these PGs levels in placenta and fetal membrane of normal pregnant rats in vivo. Placenta and fetal membrane showed positive immunoreactions for phospholipase A...

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Autores principales: SATOH, Hironori, TERASHIMA, Ryota, KAWAMINAMI, Mitsumori, KURUSU, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498834/
https://www.ncbi.nlm.nih.gov/pubmed/34334510
http://dx.doi.org/10.1292/jvms.21-0183
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author SATOH, Hironori
TERASHIMA, Ryota
KAWAMINAMI, Mitsumori
KURUSU, Shiro
author_facet SATOH, Hironori
TERASHIMA, Ryota
KAWAMINAMI, Mitsumori
KURUSU, Shiro
author_sort SATOH, Hironori
collection PubMed
description We determined a comprehensive immunohistochemistry of putative isoforms of enzymes for prostaglandin (PG) F(2)α and PGE(2) biosynthesis and these PGs levels in placenta and fetal membrane of normal pregnant rats in vivo. Placenta and fetal membrane showed positive immunoreactions for phospholipase A(2) group 4A, but not group 2A, and cyclooxygenase (COX)-1 rather than COX-2. They showed positive immunoreactions for at least one isoform of each of PGF synthase and PGE synthase with tissue-dependent variations. PGF(2)α and PGE(2) levels in both tissues were highest on day 12 and declined and remained low thereafter. Obtained data would be the basic information on the primary PGs synthesis in rat placenta and fetal membrane in normal pregnancy.
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spelling pubmed-84988342021-10-13 Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy SATOH, Hironori TERASHIMA, Ryota KAWAMINAMI, Mitsumori KURUSU, Shiro J Vet Med Sci Physiology We determined a comprehensive immunohistochemistry of putative isoforms of enzymes for prostaglandin (PG) F(2)α and PGE(2) biosynthesis and these PGs levels in placenta and fetal membrane of normal pregnant rats in vivo. Placenta and fetal membrane showed positive immunoreactions for phospholipase A(2) group 4A, but not group 2A, and cyclooxygenase (COX)-1 rather than COX-2. They showed positive immunoreactions for at least one isoform of each of PGF synthase and PGE synthase with tissue-dependent variations. PGF(2)α and PGE(2) levels in both tissues were highest on day 12 and declined and remained low thereafter. Obtained data would be the basic information on the primary PGs synthesis in rat placenta and fetal membrane in normal pregnancy. The Japanese Society of Veterinary Science 2021-07-31 2021-09 /pmc/articles/PMC8498834/ /pubmed/34334510 http://dx.doi.org/10.1292/jvms.21-0183 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Physiology
SATOH, Hironori
TERASHIMA, Ryota
KAWAMINAMI, Mitsumori
KURUSU, Shiro
Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title_full Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title_fullStr Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title_full_unstemmed Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title_short Prostaglandins F(2)α and E(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
title_sort prostaglandins f(2)α and e(2) in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498834/
https://www.ncbi.nlm.nih.gov/pubmed/34334510
http://dx.doi.org/10.1292/jvms.21-0183
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AT kawaminamimitsumori prostaglandinsf2aande2inratplacentaandfetalmembraneacomprehensiveimmunohistochemistryoftheirsyntheticenzymesandinvivotissuelevelsduringnormalpregnancy
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