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Changes in granule mobility and age contribute to changes in insulin secretion after desensitization or rest

INTRODUCTION: Functional impairment of the stimulus secretion coupling in pancreatic beta cells is an essential component of type 2 diabetes. It is known that prolonged stimulation desensitizes the secretion of insulin and thus contributes to beta cell dysfunction. Beta cell rest, in contrast, was s...

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Detalles Bibliográficos
Autores principales:	Gaus, Bastian, Brüning, Dennis, Hatlapatka, Kathrin, Rustenbeck, Ingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499263/ https://www.ncbi.nlm.nih.gov/pubmed/34620619 http://dx.doi.org/10.1136/bmjdrc-2021-002394

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