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Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol

INTRODUCTION: The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is underutilised in most parts of the world. A few...

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Autores principales: Jakobsen, Michelle Iris, Storebø, Ole Jakob, Austin, Stephen Fitzgerald, Nielsen, Jimmi, Simonsen, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499327/
https://www.ncbi.nlm.nih.gov/pubmed/34620673
http://dx.doi.org/10.1136/bmjopen-2021-054308
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author Jakobsen, Michelle Iris
Storebø, Ole Jakob
Austin, Stephen Fitzgerald
Nielsen, Jimmi
Simonsen, Erik
author_facet Jakobsen, Michelle Iris
Storebø, Ole Jakob
Austin, Stephen Fitzgerald
Nielsen, Jimmi
Simonsen, Erik
author_sort Jakobsen, Michelle Iris
collection PubMed
description INTRODUCTION: The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is underutilised in most parts of the world. A few reviews of literature addressing barriers to clozapine prescribing have been conducted. While there is some variation in the literature included in these reviews, a common feature of the studies included is that they primarily focus on clinical staff’s attitudes and perceived barriers for prescribing. Studies of patient perspectives are only sparsely included. A preliminary literature search revealed though, that additional literature on the subject exists, including literature on patient perspectives. It is therefore difficult to conclude if the formerly synthesised literature is representative of current evidence or if the topic has been adequately investigated to inform clinical practice. A scoping review is warranted in order to map and synthesise primary literature on patients’ and psychiatrists’ perspectives on clozapine treatment, and to identify gaps for future research. METHODS AND ANALYSIS: The electronic databases Cochrane Library, CINAHL, Web of Science, Psychinfo, MEDLINE and EMBASE will be searched for relevant publications, supplied with searches of Google scholar, The Networked Digital Library of Theses and Dissertations and OpenGrey. Citation tracking of selected studies will furthermore be undertaken. Two researchers will independently screen and extract data. Data will be collated to provide a descriptive summary of the literature, along with a qualitative content analysis of key findings. Identified gaps in research will be accompanied by recommendations for future investigations. ETHICS AND DISSEMINATION: Findings will be disseminated through a peer-reviewed journal and conference presentations. The scoping review does not require ethics approval.
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spelling pubmed-84993272021-10-22 Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol Jakobsen, Michelle Iris Storebø, Ole Jakob Austin, Stephen Fitzgerald Nielsen, Jimmi Simonsen, Erik BMJ Open Mental Health INTRODUCTION: The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is underutilised in most parts of the world. A few reviews of literature addressing barriers to clozapine prescribing have been conducted. While there is some variation in the literature included in these reviews, a common feature of the studies included is that they primarily focus on clinical staff’s attitudes and perceived barriers for prescribing. Studies of patient perspectives are only sparsely included. A preliminary literature search revealed though, that additional literature on the subject exists, including literature on patient perspectives. It is therefore difficult to conclude if the formerly synthesised literature is representative of current evidence or if the topic has been adequately investigated to inform clinical practice. A scoping review is warranted in order to map and synthesise primary literature on patients’ and psychiatrists’ perspectives on clozapine treatment, and to identify gaps for future research. METHODS AND ANALYSIS: The electronic databases Cochrane Library, CINAHL, Web of Science, Psychinfo, MEDLINE and EMBASE will be searched for relevant publications, supplied with searches of Google scholar, The Networked Digital Library of Theses and Dissertations and OpenGrey. Citation tracking of selected studies will furthermore be undertaken. Two researchers will independently screen and extract data. Data will be collated to provide a descriptive summary of the literature, along with a qualitative content analysis of key findings. Identified gaps in research will be accompanied by recommendations for future investigations. ETHICS AND DISSEMINATION: Findings will be disseminated through a peer-reviewed journal and conference presentations. The scoping review does not require ethics approval. BMJ Publishing Group 2021-10-07 /pmc/articles/PMC8499327/ /pubmed/34620673 http://dx.doi.org/10.1136/bmjopen-2021-054308 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Mental Health
Jakobsen, Michelle Iris
Storebø, Ole Jakob
Austin, Stephen Fitzgerald
Nielsen, Jimmi
Simonsen, Erik
Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title_full Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title_fullStr Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title_full_unstemmed Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title_short Patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
title_sort patients’ and psychiatrists’ perspectives on clozapine treatment—a scoping review protocol
topic Mental Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499327/
https://www.ncbi.nlm.nih.gov/pubmed/34620673
http://dx.doi.org/10.1136/bmjopen-2021-054308
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