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Prostaglandin D(2) metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP(2) receptor

BACKGROUND: Prostaglandin D(2) (PGD(2)) signaling via prostaglandin D(2) receptor 2 (DP(2)) contributes to atopic and non-atopic asthma. Inhibiting DP(2) has shown therapeutic benefit in certain subsets of asthma patients, improving eosinophilic airway inflammation. PGD(2) metabolites prolong the in...

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Detalles Bibliográficos
Autores principales:	Carstensen, Saskia, Gress, Christina, Erpenbeck, Veit J., Kazani, Shamsah D., Hohlfeld, Jens M., Sandham, David A., Müller, Meike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499518/ https://www.ncbi.nlm.nih.gov/pubmed/34620168 http://dx.doi.org/10.1186/s12931-021-01852-3

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