Stepwise Evolution and Exceptional Conservation of ORF1a/b Overlap in Coronaviruses

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The programmed frameshift element (PFE) rerouting translation from ORF1a to ORF1b is essential for the propagation of coronaviruses. The combination of genomic features that make up PFE—the overlap between the two reading frames, a slippery sequence, as well as an ensemble of complex secondary struc...

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Detalles Bibliográficos
Autores principales: Mei, Han, Kosakovsky Pond, Sergei, Nekrutenko, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499926/
https://www.ncbi.nlm.nih.gov/pubmed/34505896
http://dx.doi.org/10.1093/molbev/msab265

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