Theoretical basis for stabilizing messenger RNA through secondary structure design

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RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to form double-stranded regions, which are protected fr...

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Detalles Bibliográficos
Autores principales: Wayment-Steele, Hannah K, Kim, Do Soon, Choe, Christian A, Nicol, John J, Wellington-Oguri, Roger, Watkins, Andrew M, Parra Sperberg, R Andres, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499941/
https://www.ncbi.nlm.nih.gov/pubmed/34520542
http://dx.doi.org/10.1093/nar/gkab764
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