Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins

From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The corre...

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Detalles Bibliográficos
Autores principales: Karbiener, Michael, Farcet, Maria R, Schwaiger, Julia, Powers, Nicholas, Lenart, James, Stewart, Joseph M, Tallman, Hema, Kreil, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499975/
https://www.ncbi.nlm.nih.gov/pubmed/34543421
http://dx.doi.org/10.1093/infdis/jiab482
Descripción
Sumario:From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The correlation predicted anti-SARS-CoV-2 potency to reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of COVID-19 vaccinated plasma donors now result in a mean antibody titer of >600 IU/mL already in July 2021 IG lots, with SARS-CoV-2 antibody titers for several lots even higher than earlier produced hyperimmune globulin products.

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