Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins

From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The corre...

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Autores principales: Karbiener, Michael, Farcet, Maria R, Schwaiger, Julia, Powers, Nicholas, Lenart, James, Stewart, Joseph M, Tallman, Hema, Kreil, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499975/
https://www.ncbi.nlm.nih.gov/pubmed/34543421
http://dx.doi.org/10.1093/infdis/jiab482
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author Karbiener, Michael
Farcet, Maria R
Schwaiger, Julia
Powers, Nicholas
Lenart, James
Stewart, Joseph M
Tallman, Hema
Kreil, Thomas R
author_facet Karbiener, Michael
Farcet, Maria R
Schwaiger, Julia
Powers, Nicholas
Lenart, James
Stewart, Joseph M
Tallman, Hema
Kreil, Thomas R
author_sort Karbiener, Michael
collection PubMed
description From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The correlation predicted anti-SARS-CoV-2 potency to reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of COVID-19 vaccinated plasma donors now result in a mean antibody titer of >600 IU/mL already in July 2021 IG lots, with SARS-CoV-2 antibody titers for several lots even higher than earlier produced hyperimmune globulin products.
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spelling pubmed-84999752021-10-08 Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins Karbiener, Michael Farcet, Maria R Schwaiger, Julia Powers, Nicholas Lenart, James Stewart, Joseph M Tallman, Hema Kreil, Thomas R J Infect Dis Brief Report From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The correlation predicted anti-SARS-CoV-2 potency to reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of COVID-19 vaccinated plasma donors now result in a mean antibody titer of >600 IU/mL already in July 2021 IG lots, with SARS-CoV-2 antibody titers for several lots even higher than earlier produced hyperimmune globulin products. Oxford University Press 2021-09-20 /pmc/articles/PMC8499975/ /pubmed/34543421 http://dx.doi.org/10.1093/infdis/jiab482 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Karbiener, Michael
Farcet, Maria R
Schwaiger, Julia
Powers, Nicholas
Lenart, James
Stewart, Joseph M
Tallman, Hema
Kreil, Thomas R
Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title_full Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title_fullStr Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title_full_unstemmed Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title_short Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins
title_sort plasma from post-covid-19 and covid-19-vaccinated donors results in highly potent sars-cov-2 neutralization by intravenous immunoglobulins
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499975/
https://www.ncbi.nlm.nih.gov/pubmed/34543421
http://dx.doi.org/10.1093/infdis/jiab482
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