Cargando…

Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair

DNA damage is a double-edged sword for cancer cells. On the one hand, DNA damage–induced genomic instability contributes to cancer development; on the other hand, accumulating damage compromises proliferation and survival of cancer cells. Understanding the key regulators of DNA damage repair machine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Jingyi, Casey, Patrick J, Wang, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500237/ https://www.ncbi.nlm.nih.gov/pubmed/34610973 http://dx.doi.org/10.26508/lsa.202101144

Ejemplares similares

Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)
por: Baron, Rudi A, et al.
Publicado: (2004)

Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms
por: Lau, H Y, et al.
Publicado: (2017)

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome
por: Marcos-Ramiro, Beatriz, et al.
Publicado: (2021)

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal
por: Chai, Tin Fan, et al.
Publicado: (2020)

Lidocaine exerts anticancer activity in bladder cancer by targeting isoprenylcysteine carboxylmethyltransferase (ICMT)
por: Teng, Xiaodan, et al.
Publicado: (2021)

Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis
por: Do, M T, et al.
Publicado: (2017)

MicroRNA-99a-5p suppresses cell proliferation, migration, and invasion by targeting isoprenylcysteine carboxylmethyltransferase in oral squamous cell carcinoma
por: Sun, Xiang, et al.
Publicado: (2021)

Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing?
por: Grams, Danielle, et al.
Publicado: (2013)

Diazirine-Containing Photoactivatable Isoprenoid: Synthesis and Application in Studies with Isoprenylcysteine Carboxyl Methyltransferase
por: Vervacke, Jeffrey S., et al.
Publicado: (2014)

Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana
por: Lan, Ping, et al.
Publicado: (2010)

Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses
por: Yang, Woo Seok, et al.
Publicado: (2020)

Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis
por: Furlan, Daniela, et al.
Publicado: (2017)

DNA damage repair is suppressed in porcine aged oocytes
por: Lin, Tao, et al.
Publicado: (2021)

Compromised DNA repair is responsible for diabetes‐associated fibrosis
por: Kumar, Varun, et al.
Publicado: (2020)

Sperm DNA damage compromises embryo development, but not oocyte fertilisation in pigs
por: Mateo-Otero, Yentel, et al.
Publicado: (2022)

DNA damage and repair in the hematopoietic system: DNA damage and repair in the hematopoietic system
por: Li, Niu, et al.
Publicado: (2022)

Sting and p53 DNA repair pathways are compromised in Alzheimer’s disease
por: Nelson, Thomas J., et al.
Publicado: (2023)

ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair
por: Brown, Adam D., et al.
Publicado: (2014)

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors
por: Xia, Yuntao, et al.
Publicado: (2018)

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability
por: Lu, Yuxiong, et al.
Publicado: (2018)

Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation
por: Yu, Tzu-Jung, et al.
Publicado: (2022)

Taking a Bad Turn: Compromised DNA Damage Response in Leukemia
por: Nilles, Nadine, et al.
Publicado: (2017)

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
por: Iwai, Kenichi, et al.
Publicado: (2021)

Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
por: Hart, Madeleine, et al.
Publicado: (2021)

The Role of Dicer in DNA Damage Repair
por: Tang, Kai-Fu, et al.
Publicado: (2012)

Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes
por: Cheng, Lei, et al.
Publicado: (2018)

Repair of radiation damage to DNA
por: Willers, H, et al.
Publicado: (2004)

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair
por: Nair, Nidhi, et al.
Publicado: (2017)

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair
por: Chen, Yu-An, et al.
Publicado: (2018)

Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness
por: Pieren, Daan K. J., et al.
Publicado: (2021)

Intragenomic repair heterogeneity of DNA damage.
por: Scicchitano, D A, et al.
Publicado: (1992)

DNA Damage, Mutagenesis, and DNA Repair
por: Basu, Ashis, et al.
Publicado: (2010)

Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
por: Lin, Shiaw-Yih, et al.
Publicado: (2010)

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
por: Rochette, Patrick J., et al.
Publicado: (2010)

DNA Damage, Homology-Directed Repair, and DNA Methylation
por: Cuozzo, Concetta, et al.
Publicado: (2007)

Boris knockout eliminates AOM/DSS‐induced in situ colorectal cancer by suppressing DNA damage repair and inflammation
por: Zuo, Bo‐Wen, et al.
Publicado: (2023)

DNA Damage, Repair, and Diseases
por: Wiesmüller, Lisa, et al.
Publicado: (2002)

Aptamers for DNA Damage and Repair
por: McKeague, Maureen
Publicado: (2017)

The EMSY threonine 207 phospho-site is required for EMSY-driven suppression of DNA damage repair
por: Jelinic, Petar, et al.
Publicado: (2017)

miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells
por: He, Mingyang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5846e0bmpa52anu5ndcj9e2rqo