Use of Tocilizumab May Avoid the Need of Invasive Ventilation

Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Increased pro-inflammatory cytokines including interleukin 6 (IL-6) are associated with severe forms of illnesses. The severe cases of COVID-19 require a high amount of oxygen su...

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Detalles Bibliográficos
Autores principales: Adhikari, Anurag, Poudel, Ayusha, Pandey, Oshna, Aryal, Barun B, Dhungana, Bibek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500242/
https://www.ncbi.nlm.nih.gov/pubmed/34660032
http://dx.doi.org/10.7759/cureus.17822
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author Adhikari, Anurag
Poudel, Ayusha
Pandey, Oshna
Aryal, Barun B
Dhungana, Bibek
author_facet Adhikari, Anurag
Poudel, Ayusha
Pandey, Oshna
Aryal, Barun B
Dhungana, Bibek
author_sort Adhikari, Anurag
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Increased pro-inflammatory cytokines including interleukin 6 (IL-6) are associated with severe forms of illnesses. The severe cases of COVID-19 require a high amount of oxygen supplementation and might even require endotracheal intubation with ventilator support. A blockade of inflammatory cascade with the use of tocilizumab has been shown to decrease the need for intubation and ventilator requirement.
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spelling pubmed-85002422021-10-14 Use of Tocilizumab May Avoid the Need of Invasive Ventilation Adhikari, Anurag Poudel, Ayusha Pandey, Oshna Aryal, Barun B Dhungana, Bibek Cureus Internal Medicine Coronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Increased pro-inflammatory cytokines including interleukin 6 (IL-6) are associated with severe forms of illnesses. The severe cases of COVID-19 require a high amount of oxygen supplementation and might even require endotracheal intubation with ventilator support. A blockade of inflammatory cascade with the use of tocilizumab has been shown to decrease the need for intubation and ventilator requirement. Cureus 2021-09-08 /pmc/articles/PMC8500242/ /pubmed/34660032 http://dx.doi.org/10.7759/cureus.17822 Text en Copyright © 2021, Adhikari et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Adhikari, Anurag
Poudel, Ayusha
Pandey, Oshna
Aryal, Barun B
Dhungana, Bibek
Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title_full Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title_fullStr Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title_full_unstemmed Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title_short Use of Tocilizumab May Avoid the Need of Invasive Ventilation
title_sort use of tocilizumab may avoid the need of invasive ventilation
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500242/
https://www.ncbi.nlm.nih.gov/pubmed/34660032
http://dx.doi.org/10.7759/cureus.17822
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