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The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study

PURPOSE: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features. PATIENTS AND METHODS: A cross-sectional case-control study of 21 patients with PD and 22 age-matched heal...

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Autores principales: Cesareo, Massimo, Di Marco, Ernesto, Giannini, Clarissa, Di Marino, Matteo, Aiello, Francesco, Pisani, Antonio, Pierantozzi, Mariangela, Mercuri, Nicola Biagio, Nucci, Carlo, Mancino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500491/
https://www.ncbi.nlm.nih.gov/pubmed/34675469
http://dx.doi.org/10.2147/OPTH.S323944
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author Cesareo, Massimo
Di Marco, Ernesto
Giannini, Clarissa
Di Marino, Matteo
Aiello, Francesco
Pisani, Antonio
Pierantozzi, Mariangela
Mercuri, Nicola Biagio
Nucci, Carlo
Mancino, Raffaele
author_facet Cesareo, Massimo
Di Marco, Ernesto
Giannini, Clarissa
Di Marino, Matteo
Aiello, Francesco
Pisani, Antonio
Pierantozzi, Mariangela
Mercuri, Nicola Biagio
Nucci, Carlo
Mancino, Raffaele
author_sort Cesareo, Massimo
collection PubMed
description PURPOSE: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features. PATIENTS AND METHODS: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL). RESULTS: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13–16.2] vs 17.95 [16.08–18.96] p<0.0001). CONCLUSION: Our results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD.
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spelling pubmed-85004912021-10-20 The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study Cesareo, Massimo Di Marco, Ernesto Giannini, Clarissa Di Marino, Matteo Aiello, Francesco Pisani, Antonio Pierantozzi, Mariangela Mercuri, Nicola Biagio Nucci, Carlo Mancino, Raffaele Clin Ophthalmol Original Research PURPOSE: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features. PATIENTS AND METHODS: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL). RESULTS: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13–16.2] vs 17.95 [16.08–18.96] p<0.0001). CONCLUSION: Our results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD. Dove 2021-10-04 /pmc/articles/PMC8500491/ /pubmed/34675469 http://dx.doi.org/10.2147/OPTH.S323944 Text en © 2021 Cesareo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Cesareo, Massimo
Di Marco, Ernesto
Giannini, Clarissa
Di Marino, Matteo
Aiello, Francesco
Pisani, Antonio
Pierantozzi, Mariangela
Mercuri, Nicola Biagio
Nucci, Carlo
Mancino, Raffaele
The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title_full The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title_fullStr The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title_full_unstemmed The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title_short The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study
title_sort retinal posterior pole in early parkinson’s disease: a fundus perimetry and sd-oct study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500491/
https://www.ncbi.nlm.nih.gov/pubmed/34675469
http://dx.doi.org/10.2147/OPTH.S323944
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