Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

Molecular pathways controlling emigration of mature thymocytes from thymus to the periphery remain incompletely understood. Here, we show that T cell–specific ablation of glycogen synthase kinase 3 (GSK3) led to severely impaired thymic egress. In the absence of GSK3, β-catenin accumulated in the cy...

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Detalles Bibliográficos
Autores principales: Liu, Chenfeng, Ma, Lei, Wang, Yuxuan, Zhao, Jiayi, Chen, Pengda, Chen, Xian, Wang, Yingxin, Hu, Yanyan, Liu, Yun, Jia, Xian, Yang, Zhanghua, Yin, Xingzhi, Wu, Jianfeng, Wu, Suqin, Zheng, Haiping, Ma, Xiaohong, Sun, Xiufeng, He, Ying, Lin, Lianghua, Fu, Yubing, Liao, Kunyu, Zhou, Xiaojuan, Jiang, Shan, Fu, Guofeng, Tang, Jian, Han, Wei, Chen, Xiao Lei, Fan, Wenzhu, Hong, Yazhen, Han, Jiahuai, Huang, Xiangyang, Li, Bo-An, Xiao, Nengming, Xiao, Changchun, Fu, Guo, Liu, Wen-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500522/
https://www.ncbi.nlm.nih.gov/pubmed/34623920
http://dx.doi.org/10.1126/sciadv.abg6262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500522/
https://www.ncbi.nlm.nih.gov/pubmed/34623920
http://dx.doi.org/10.1126/sciadv.abg6262

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