Clinical significance of overweight in patients with hypertrophic cardiomyopathy: A retrospective cohort study

Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease with varying clinical outcomes and it is important to identify new predictors of adverse events and survival in HCM patients. Overweight may independently predict the clinical outcomes of HCM patients. This was a retrospective study. Two hundred six HCM patients were compared classified by the normal group (body mass index < 25 kg/m(2)) and the overweight group (body mass index ≥ 25 kg/m(2)). We compared major adverse cardiovascular and cerebral events and secondary endpoints between 2 groups. By Cox analysis, we determined whether overweight was an independent predictor of MACCE in HCM patients. Finally, we also explored the prognostic value of overweight on all-cause death in HCM cohorts using Kaplan–Meier analysis. Overweight patients were associated with more heart failure (HF) rehospitalization in HCM patients (51.3% vs 27.5%, P = .001). Overweight was an independent determinant of MACCE in HCM patients (heart rate = 3.40, 95% confidence interval: 1.79–6.61, P < .001), mainly attributed to HF rehospitalization (heart rate = 3.44, 95% confidence interval: 1.64–6.72, P < .001). However, a prognostic effect of overweight on overall survival was not observed by Kaplan–Meier analysis (P = .23). These results provide the evidence that overweight could predict the presence of MACCE, especially HF rehospitalization, in HCM patients.