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Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500559/ https://www.ncbi.nlm.nih.gov/pubmed/34622850 http://dx.doi.org/10.1097/MD.0000000000027420 |
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author | Shibata, Yusuke Yamazaki, Masanori Kitahara, Junichiro Okubo, Yosuke Oiwa, Ako Sato, Ai Komatsu, Mitsuhisa |
author_facet | Shibata, Yusuke Yamazaki, Masanori Kitahara, Junichiro Okubo, Yosuke Oiwa, Ako Sato, Ai Komatsu, Mitsuhisa |
author_sort | Shibata, Yusuke |
collection | PubMed |
description | Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observational study, we enrolled 268 Japanese people with T2DM aged ≥20 years who were followed up at Shinshu University Hospital. Among those, 112 eligible individuals aged ≥65 years were included in the present study. Factors associated with 3-year changes in eGFR (ΔeGFR) and eGFR deterioration (ΔeGFR < 0) were identified using bivariate and multivariable analyses. Regarding baseline values of the subjects, the mean age was 73.5 years, mean blood pressure was 131/74 mm Hg, mean hemoglobin A1c was 7.1%, mean eGFR was 62.0 mL/min/1.73 m(2), mean urinary albumin excretion was 222.6 mg/gCre, and mean serum uric acid (UA) was 5.5 mg/mL. In bivariate analysis, the 3-year change in UA (ΔUA) levels was significantly correlated with ΔeGFR (r = −0.491, P < .001), but the baseline UA was not (r = 0.073, P = .444). Multiple linear regression analysis revealed that ΔUA was a significant negative predictor of ΔeGFR in the model that included sex, age, body mass index, serum albumin, and ΔUA as explanatory variables. Moreover, multiple logistic regression analysis demonstrated that ΔUA had a positive association with ΔeGFR <0 (odds ratio 2.374; 95% confidence interval 1.294–4.357). Thus, future renal function decline can be predicted by ΔUA but not by baseline UA in older adults with T2DM. Further research is needed to determine whether lowering the serum UA level can prevent eGFR decline. |
format | Online Article Text |
id | pubmed-8500559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-85005592021-10-12 Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes Shibata, Yusuke Yamazaki, Masanori Kitahara, Junichiro Okubo, Yosuke Oiwa, Ako Sato, Ai Komatsu, Mitsuhisa Medicine (Baltimore) 4600 Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observational study, we enrolled 268 Japanese people with T2DM aged ≥20 years who were followed up at Shinshu University Hospital. Among those, 112 eligible individuals aged ≥65 years were included in the present study. Factors associated with 3-year changes in eGFR (ΔeGFR) and eGFR deterioration (ΔeGFR < 0) were identified using bivariate and multivariable analyses. Regarding baseline values of the subjects, the mean age was 73.5 years, mean blood pressure was 131/74 mm Hg, mean hemoglobin A1c was 7.1%, mean eGFR was 62.0 mL/min/1.73 m(2), mean urinary albumin excretion was 222.6 mg/gCre, and mean serum uric acid (UA) was 5.5 mg/mL. In bivariate analysis, the 3-year change in UA (ΔUA) levels was significantly correlated with ΔeGFR (r = −0.491, P < .001), but the baseline UA was not (r = 0.073, P = .444). Multiple linear regression analysis revealed that ΔUA was a significant negative predictor of ΔeGFR in the model that included sex, age, body mass index, serum albumin, and ΔUA as explanatory variables. Moreover, multiple logistic regression analysis demonstrated that ΔUA had a positive association with ΔeGFR <0 (odds ratio 2.374; 95% confidence interval 1.294–4.357). Thus, future renal function decline can be predicted by ΔUA but not by baseline UA in older adults with T2DM. Further research is needed to determine whether lowering the serum UA level can prevent eGFR decline. Lippincott Williams & Wilkins 2021-10-08 /pmc/articles/PMC8500559/ /pubmed/34622850 http://dx.doi.org/10.1097/MD.0000000000027420 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4600 Shibata, Yusuke Yamazaki, Masanori Kitahara, Junichiro Okubo, Yosuke Oiwa, Ako Sato, Ai Komatsu, Mitsuhisa Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title | Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title_full | Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title_fullStr | Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title_full_unstemmed | Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title_short | Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
title_sort | changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes |
topic | 4600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500559/ https://www.ncbi.nlm.nih.gov/pubmed/34622850 http://dx.doi.org/10.1097/MD.0000000000027420 |
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