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Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes

Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observa...

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Autores principales: Shibata, Yusuke, Yamazaki, Masanori, Kitahara, Junichiro, Okubo, Yosuke, Oiwa, Ako, Sato, Ai, Komatsu, Mitsuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500559/
https://www.ncbi.nlm.nih.gov/pubmed/34622850
http://dx.doi.org/10.1097/MD.0000000000027420
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author Shibata, Yusuke
Yamazaki, Masanori
Kitahara, Junichiro
Okubo, Yosuke
Oiwa, Ako
Sato, Ai
Komatsu, Mitsuhisa
author_facet Shibata, Yusuke
Yamazaki, Masanori
Kitahara, Junichiro
Okubo, Yosuke
Oiwa, Ako
Sato, Ai
Komatsu, Mitsuhisa
author_sort Shibata, Yusuke
collection PubMed
description Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observational study, we enrolled 268 Japanese people with T2DM aged ≥20 years who were followed up at Shinshu University Hospital. Among those, 112 eligible individuals aged ≥65 years were included in the present study. Factors associated with 3-year changes in eGFR (ΔeGFR) and eGFR deterioration (ΔeGFR < 0) were identified using bivariate and multivariable analyses. Regarding baseline values of the subjects, the mean age was 73.5 years, mean blood pressure was 131/74 mm Hg, mean hemoglobin A1c was 7.1%, mean eGFR was 62.0 mL/min/1.73 m(2), mean urinary albumin excretion was 222.6 mg/gCre, and mean serum uric acid (UA) was 5.5 mg/mL. In bivariate analysis, the 3-year change in UA (ΔUA) levels was significantly correlated with ΔeGFR (r = −0.491, P < .001), but the baseline UA was not (r = 0.073, P = .444). Multiple linear regression analysis revealed that ΔUA was a significant negative predictor of ΔeGFR in the model that included sex, age, body mass index, serum albumin, and ΔUA as explanatory variables. Moreover, multiple logistic regression analysis demonstrated that ΔUA had a positive association with ΔeGFR <0 (odds ratio 2.374; 95% confidence interval 1.294–4.357). Thus, future renal function decline can be predicted by ΔUA but not by baseline UA in older adults with T2DM. Further research is needed to determine whether lowering the serum UA level can prevent eGFR decline.
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spelling pubmed-85005592021-10-12 Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes Shibata, Yusuke Yamazaki, Masanori Kitahara, Junichiro Okubo, Yosuke Oiwa, Ako Sato, Ai Komatsu, Mitsuhisa Medicine (Baltimore) 4600 Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observational study, we enrolled 268 Japanese people with T2DM aged ≥20 years who were followed up at Shinshu University Hospital. Among those, 112 eligible individuals aged ≥65 years were included in the present study. Factors associated with 3-year changes in eGFR (ΔeGFR) and eGFR deterioration (ΔeGFR < 0) were identified using bivariate and multivariable analyses. Regarding baseline values of the subjects, the mean age was 73.5 years, mean blood pressure was 131/74 mm Hg, mean hemoglobin A1c was 7.1%, mean eGFR was 62.0 mL/min/1.73 m(2), mean urinary albumin excretion was 222.6 mg/gCre, and mean serum uric acid (UA) was 5.5 mg/mL. In bivariate analysis, the 3-year change in UA (ΔUA) levels was significantly correlated with ΔeGFR (r = −0.491, P < .001), but the baseline UA was not (r = 0.073, P = .444). Multiple linear regression analysis revealed that ΔUA was a significant negative predictor of ΔeGFR in the model that included sex, age, body mass index, serum albumin, and ΔUA as explanatory variables. Moreover, multiple logistic regression analysis demonstrated that ΔUA had a positive association with ΔeGFR <0 (odds ratio 2.374; 95% confidence interval 1.294–4.357). Thus, future renal function decline can be predicted by ΔUA but not by baseline UA in older adults with T2DM. Further research is needed to determine whether lowering the serum UA level can prevent eGFR decline. Lippincott Williams & Wilkins 2021-10-08 /pmc/articles/PMC8500559/ /pubmed/34622850 http://dx.doi.org/10.1097/MD.0000000000027420 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4600
Shibata, Yusuke
Yamazaki, Masanori
Kitahara, Junichiro
Okubo, Yosuke
Oiwa, Ako
Sato, Ai
Komatsu, Mitsuhisa
Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title_full Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title_fullStr Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title_full_unstemmed Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title_short Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
title_sort changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
topic 4600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500559/
https://www.ncbi.nlm.nih.gov/pubmed/34622850
http://dx.doi.org/10.1097/MD.0000000000027420
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