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COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative
Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality in solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested for COVID-19 across the United States. METHODS. In t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500600/ https://www.ncbi.nlm.nih.gov/pubmed/34646938 http://dx.doi.org/10.1097/TXD.0000000000001234 |
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author | Vinson, Amanda J. Agarwal, Gaurav Dai, Ran Anzalone, Alfred J. Lee, Stephen B. French, Evan Olex, Amy Madhira, Vithal Mannon, Roslyn B. |
author_facet | Vinson, Amanda J. Agarwal, Gaurav Dai, Ran Anzalone, Alfred J. Lee, Stephen B. French, Evan Olex, Amy Madhira, Vithal Mannon, Roslyn B. |
author_sort | Vinson, Amanda J. |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality in solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested for COVID-19 across the United States. METHODS. In this study, we identified a cohort of SOT recipients testing positive or negative for COVID-19 (COVID+ and COVID−, respectively) between January 1, 2020, and November 20, 2020. Univariable and multivariable logistic regression were used to determine predictors of a positive result among those tested. Outcomes following COVID-19 diagnosis were also explored. RESULTS. Of 18 121 SOT patients tested, 1925 were positive (10.6%). COVID+ SOT patients were more likely to have a kidney transplant and be non-White race. Comorbidities were common in all SOT patients but significantly more common in those who were COVID+. Of COVID+ SOT, 42.9% required hospital admission. COVID+ status was the strongest predictor of acute kidney injury (AKI), rejection, and graft failure in the 90 d after testing. A total of 40.9% of COVID+ SOT experienced a major adverse renal or cardiac event, 16.3% experienced a major adverse cardiac event, 35.3% experienced AKI, and 1.5% experienced graft loss. CONCLUSIONS. In the largest US cohort of COVID+ SOT recipients to date, we identified patient factors associated with the diagnosis of COVID-19 and outcomes following infection, including a high incidence of major adverse renal or cardiac event and AKI. |
format | Online Article Text |
id | pubmed-8500600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-85006002021-10-12 COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative Vinson, Amanda J. Agarwal, Gaurav Dai, Ran Anzalone, Alfred J. Lee, Stephen B. French, Evan Olex, Amy Madhira, Vithal Mannon, Roslyn B. Transplant Direct Infectious Disease Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality in solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested for COVID-19 across the United States. METHODS. In this study, we identified a cohort of SOT recipients testing positive or negative for COVID-19 (COVID+ and COVID−, respectively) between January 1, 2020, and November 20, 2020. Univariable and multivariable logistic regression were used to determine predictors of a positive result among those tested. Outcomes following COVID-19 diagnosis were also explored. RESULTS. Of 18 121 SOT patients tested, 1925 were positive (10.6%). COVID+ SOT patients were more likely to have a kidney transplant and be non-White race. Comorbidities were common in all SOT patients but significantly more common in those who were COVID+. Of COVID+ SOT, 42.9% required hospital admission. COVID+ status was the strongest predictor of acute kidney injury (AKI), rejection, and graft failure in the 90 d after testing. A total of 40.9% of COVID+ SOT experienced a major adverse renal or cardiac event, 16.3% experienced a major adverse cardiac event, 35.3% experienced AKI, and 1.5% experienced graft loss. CONCLUSIONS. In the largest US cohort of COVID+ SOT recipients to date, we identified patient factors associated with the diagnosis of COVID-19 and outcomes following infection, including a high incidence of major adverse renal or cardiac event and AKI. Lippincott Williams & Wilkins 2021-10-06 /pmc/articles/PMC8500600/ /pubmed/34646938 http://dx.doi.org/10.1097/TXD.0000000000001234 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Infectious Disease Vinson, Amanda J. Agarwal, Gaurav Dai, Ran Anzalone, Alfred J. Lee, Stephen B. French, Evan Olex, Amy Madhira, Vithal Mannon, Roslyn B. COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title | COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title_full | COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title_fullStr | COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title_full_unstemmed | COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title_short | COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative |
title_sort | covid-19 in solid organ transplantation: results of the national covid cohort collaborative |
topic | Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500600/ https://www.ncbi.nlm.nih.gov/pubmed/34646938 http://dx.doi.org/10.1097/TXD.0000000000001234 |
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