A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in human cancers. However, inhibitors that block protein-protein interactions (PPIs) between WDR5 and its binding partners exhibit...

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Detalles Bibliográficos
Autores principales: Yu, Xufen, Li, Dongxu, Kottur, Jithesh, Shen, Yudao, Kim, Huen Suk, Park, Kwang-Su, Tsai, Yi-Hsuan, Gong, Weida, Wang, Jun, Suzuki, Kyogo, Parker, Joel, Herring, Laura, Kaniskan, H. Ümit, Cai, Ling, Jain, Rinku, Liu, Jing, Aggarwal, Aneel K, Wang, Gang Greg, Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500670/
https://www.ncbi.nlm.nih.gov/pubmed/34586829
http://dx.doi.org/10.1126/scitranslmed.abj1578

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