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A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas. Somatic inactivation of NF1 and cooperating tumor suppressors, including CDKN2A/B, PRC2, and p53, is found in most MPNST. Inactivation of LATS1/2 of the Hippo pathway was recently shown to cause tumors resembling M...

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Detalles Bibliográficos
Autores principales:	Inoue, Akira, Janke, Laura J, Gudenas, Brian L, Jin, Hongjian, Fan, Yiping, Paré, Joshua, Clay, Michael R, Northcott, Paul A, Hirbe, Angela C, Cao, Xinwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500687/ https://www.ncbi.nlm.nih.gov/pubmed/34647023 http://dx.doi.org/10.1093/noajnl/vdab129

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