Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport

BACKGROUND: Pharmaceutical intervention in the CNS is hampered by the shielding function of the blood–brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as isoflurane readily penetrate the BBB. Here, we investigated whether isoflurane can be utilized for therapeutic drug de...

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Detalles Bibliográficos
Autores principales: Spieth, Lena, Berghoff, Stefan A, Stumpf, Sina K, Winchenbach, Jan, Michaelis, Thomas, Watanabe, Takashi, Gerndt, Nina, Düking, Tim, Hofer, Sabine, Ruhwedel, Torben, Shaib, Ali H, Willig, Katrin, Kronenberg, Katharina, Karst, Uwe, Frahm, Jens, Rhee, Jeong Seop, Minguet, Susana, Möbius, Wiebke, Kruse, Niels, von der Brelie, Christian, Michels, Peter, Stadelmann, Christine, Hülper, Petra, Saher, Gesine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500692/
https://www.ncbi.nlm.nih.gov/pubmed/34647026
http://dx.doi.org/10.1093/noajnl/vdab140

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