3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal hemoglobin (HPFH), has been found to ameliorate hemogl...

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Detalles Bibliográficos
Autores principales: Himadewi, Pamela, Wang, Xue Qing David, Feng, Fan, Gore, Haley, Liu, Yushuai, Yu, Lei, Kurita, Ryo, Nakamura, Yukio, Pfeifer, Gerd P, Liu, Jie, Zhang, Xiaotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500713/
https://www.ncbi.nlm.nih.gov/pubmed/34585664
http://dx.doi.org/10.7554/eLife.70557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500713/
https://www.ncbi.nlm.nih.gov/pubmed/34585664
http://dx.doi.org/10.7554/eLife.70557

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