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3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal hemoglobin (HPFH), has been found to ameliorate hemogl...
Autores principales: | Himadewi, Pamela, Wang, Xue Qing David, Feng, Fan, Gore, Haley, Liu, Yushuai, Yu, Lei, Kurita, Ryo, Nakamura, Yukio, Pfeifer, Gerd P, Liu, Jie, Zhang, Xiaotian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500713/ https://www.ncbi.nlm.nih.gov/pubmed/34585664 http://dx.doi.org/10.7554/eLife.70557 |
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