Cargando…

Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways

OBJECTIVE: To investigate the effect of electroacupuncture (EA) on cognitive dysfunction in rats with hepatic encephalopathy and its underlying mechanism. METHODS: Fifty Wistar rats were randomly divided into a normal group (n = 10) and model group (n = 40). Rat models of hepatic encephalopathy were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Jiling, Gong, Zhigang, Kong, Yingnan, Huang, Yanwen, Wang, Hui, Kang, Yingjie, Zhan, Songhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500758/ https://www.ncbi.nlm.nih.gov/pubmed/34630618 http://dx.doi.org/10.1155/2021/7992688

Ejemplares similares

A true response of the brain network during electroacupuncture stimulation at scalp acupoints: An fMRI with simultaneous EAS study
por: Chen, Hui, et al.
Publicado: (2022)

Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway
por: Gao, Ruyi, et al.
Publicado: (2020)

TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection
por: Kuriakose, Shiby, et al.
Publicado: (2019)

SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo
por: Chaves de Souza, João Antônio, et al.
Publicado: (2013)

Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats
por: Wang, Jun-ying, et al.
Publicado: (2015)

Electroacupuncture Inhibits the Activation of p38MAPK in the Central Descending Facilitatory Pathway in Rats with Inflammatory Pain
por: Hu, Man-Li, et al.
Publicado: (2017)

CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway
por: Shen, Yanan, et al.
Publicado: (2021)

MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3
por: Bian, Hongjun, et al.
Publicado: (2017)

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
por: Bachstetter, Adam D, et al.
Publicado: (2011)

Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway
por: O'Dea, Kieran P., et al.
Publicado: (2011)

ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
por: Nahirnyj, Adrian, et al.
Publicado: (2013)

Toxic proteins from Croton tiglium L. exert a proinflammatory effect by inducing release of proinflammatory cytokines and activating the p38-MAPK signaling pathway
por: Liu, Liping, et al.
Publicado: (2017)

Interplay between nuclear factor-κB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells
por: Bansal, Akanksha, et al.
Publicado: (2022)

Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability
por: Wang, Weiju, et al.
Publicado: (2018)

Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association
por: Conti, Filippo, et al.
Publicado: (2015)

Role of p38 MAPK and STAT3 in lipopolysaccharide-stimulated mouse alveolar macrophages
por: MENG, AIHONG, et al.
Publicado: (2014)

Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain
por: Liang, Yi, et al.
Publicado: (2012)

Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs
por: Chen, Kun, et al.
Publicado: (2017)

Electroacupuncture pretreatment protects against anesthesia/surgery-induced cognitive decline by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region in aged rats
por: Huang, Hongjie, et al.
Publicado: (2023)

Electroacupuncture Ameliorates Cognitive Impairment by Inhibiting the JNK Signaling Pathway in a Mouse Model of Alzheimer’s Disease
por: Tang, Yinshan, et al.
Publicado: (2020)

Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats
por: Fang, Jian-Qiao, et al.
Publicado: (2013)

Astaxanthin Attenuates Environmental Tobacco Smoke-Induced Cognitive Deficits: A Critical Role of p38 MAPK
por: Yang, Xia, et al.
Publicado: (2019)

Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release
por: Poecheim, Johanna, et al.
Publicado: (2015)

Giardia duodenalis Induces Proinflammatory Cytokine Production in Mouse Macrophages via TLR9-Mediated p38 and ERK Signaling Pathways
por: Pu, Xudong, et al.
Publicado: (2021)

Essential role of mitochondrial Stat3 in p38(MAPK) mediated apoptosis under oxidative stress
por: Cheng, Xinlai, et al.
Publicado: (2017)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling
por: Kim, Jieun, et al.
Publicado: (2022)

High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways
por: Xiao, Ze Xiu, et al.
Publicado: (2020)

Electroacupuncture for Cancer-Related Cognitive Impairment: A Clinical Feasibility Study
por: Lyu, Yee Ran, et al.
Publicado: (2022)

Cognitive Improvement Effects of Electroacupuncture Combined with Computer-Based Cognitive Rehabilitation in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial
por: Kim, Jae-Hong, et al.
Publicado: (2020)

PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
por: Peng, Hui, et al.
Publicado: (2022)

17-β-estradiol inhibits hyperosmolarity-induced proinflammatory cytokine elevation via the p38 MAPK pathway in human corneal epithelial cells
por: Wang, Changjun, et al.
Publicado: (2012)

TLR Signaling Paralyzes Monocyte Chemotaxis through Synergized Effects of p38 MAPK and Global Rap-1 Activation
por: Yi, Ling, et al.
Publicado: (2012)

The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis
por: Bolourani, Siavash, et al.
Publicado: (2021)

Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis
por: Li, Jiaxin, et al.
Publicado: (2017)

Characteristics of Dysregulated Proinflammatory Cytokines and Cognitive Dysfunction in Late-Life Depression and Amnestic Mild Cognitive Impairment
por: Nie, Jing, et al.
Publicado: (2022)

Cognitive impairment after liver transplantation: residual hepatic encephalopathy or posttransplant encephalopathy?
por: Kornerup, Linda Skibsted, et al.
Publicado: (2019)

Crosstalk between signals initiated from TLR4 and cell surface BAFF results in synergistic induction of proinflammatory mediators in THP-1 cells
por: Lim, Su-Geun, et al.
Publicado: (2017)

Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells
por: Shih, Jui-Hu, et al.
Publicado: (2020)

Electroacupuncture Pretreatment Elicits Tolerance to Cerebral Ischemia/Reperfusion through Inhibition of the GluN2B/m-Calpain/p38 MAPK Proapoptotic Pathway
por: Zhang, Bao-yu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kg7qvsbau4b57apo3u2iht259s