Clinical and immunological characteristics in COVID-19 convalescent patients

The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of me...

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Autores principales: Su, Zhiying, Hu, Wenjia, Liu, Qianyun, Zhang, Yongxi, Chen, Tielong, Zhou, Yingying, Zhang, Zhen, Chen, Yu, Yang, Rongrong, Xiong, Yong, Wang, Xinghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500824/
https://www.ncbi.nlm.nih.gov/pubmed/34625887
http://dx.doi.org/10.1007/s10096-021-04360-w
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author Su, Zhiying
Hu, Wenjia
Liu, Qianyun
Zhang, Yongxi
Chen, Tielong
Zhou, Yingying
Zhang, Zhen
Chen, Yu
Yang, Rongrong
Xiong, Yong
Wang, Xinghuan
author_facet Su, Zhiying
Hu, Wenjia
Liu, Qianyun
Zhang, Yongxi
Chen, Tielong
Zhou, Yingying
Zhang, Zhen
Chen, Yu
Yang, Rongrong
Xiong, Yong
Wang, Xinghuan
author_sort Su, Zhiying
collection PubMed
description The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4(+) T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.
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spelling pubmed-85008242021-10-12 Clinical and immunological characteristics in COVID-19 convalescent patients Su, Zhiying Hu, Wenjia Liu, Qianyun Zhang, Yongxi Chen, Tielong Zhou, Yingying Zhang, Zhen Chen, Yu Yang, Rongrong Xiong, Yong Wang, Xinghuan Eur J Clin Microbiol Infect Dis Brief Report The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4(+) T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection. Springer Berlin Heidelberg 2021-10-09 2021 /pmc/articles/PMC8500824/ /pubmed/34625887 http://dx.doi.org/10.1007/s10096-021-04360-w Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Su, Zhiying
Hu, Wenjia
Liu, Qianyun
Zhang, Yongxi
Chen, Tielong
Zhou, Yingying
Zhang, Zhen
Chen, Yu
Yang, Rongrong
Xiong, Yong
Wang, Xinghuan
Clinical and immunological characteristics in COVID-19 convalescent patients
title Clinical and immunological characteristics in COVID-19 convalescent patients
title_full Clinical and immunological characteristics in COVID-19 convalescent patients
title_fullStr Clinical and immunological characteristics in COVID-19 convalescent patients
title_full_unstemmed Clinical and immunological characteristics in COVID-19 convalescent patients
title_short Clinical and immunological characteristics in COVID-19 convalescent patients
title_sort clinical and immunological characteristics in covid-19 convalescent patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500824/
https://www.ncbi.nlm.nih.gov/pubmed/34625887
http://dx.doi.org/10.1007/s10096-021-04360-w
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