The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes

Xkr8–Basigin is a plasma membrane phospholipid scramblase activated by kinases or caspases. We combined cryo-EM and X-ray crystallography to investigate its structure at an overall resolution of 3.8 Å. Its membrane-spanning region carrying 22 charged amino acids adopts a cuboid-like structure stabil...

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Detalles Bibliográficos
Autores principales: Sakuragi, Takaharu, Kanai, Ryuta, Tsutsumi, Akihisa, Narita, Hirotaka, Onishi, Eriko, Nishino, Kohei, Miyazaki, Takuya, Baba, Takeshi, Kosako, Hidetaka, Nakagawa, Atsushi, Kikkawa, Masahide, Toyoshima, Chikashi, Nagata, Shigekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500837/
https://www.ncbi.nlm.nih.gov/pubmed/34625749
http://dx.doi.org/10.1038/s41594-021-00665-8

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