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Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology

OBJECTIVE: The development of Alzheimer’s disease (AD) can be assessed using the neuropsychological test battery Vienna (NTBV). The objective of this study was to investigate whether the NTBV test scores of a diagnostic group have changed significantly over time and whether this change is due to dis...

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Autores principales: Rosas, Anna Garcia, Stögmann, Elisabeth, Lehrner, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500870/
https://www.ncbi.nlm.nih.gov/pubmed/33095320
http://dx.doi.org/10.1007/s00508-020-01755-1
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author Rosas, Anna Garcia
Stögmann, Elisabeth
Lehrner, Johann
author_facet Rosas, Anna Garcia
Stögmann, Elisabeth
Lehrner, Johann
author_sort Rosas, Anna Garcia
collection PubMed
description OBJECTIVE: The development of Alzheimer’s disease (AD) can be assessed using the neuropsychological test battery Vienna (NTBV). The objective of this study was to investigate whether the NTBV test scores of a diagnostic group have changed significantly over time and whether this change is due to disease progression. METHODS: In this study 358 patients referred to a memory outpatient clinic because of cognitive deterioration were analyzed. The same patients were surveyed in a follow-up assessment after a mean interval of 25.96 months to examine cognitive performance and disease progression. Patients were divided into the subgroups healthy controls (HC), subjective cognitive decline (SCD), mild cognitive impairment (MCI) and AD on the basis of the test results. Reliable change index methodology was used to assess improvement or deterioration in test scores in diagnostic groups compared to HC. RESULTS: Deterioration in the SCD group ranged from 0% to 18.8%. The MCI group showed declines between 1.6% and 29.1%. Patients who developed AD deteriorated between 0% and 54.2%. Improvements ranged from 0% to 73.4% in the SCD group and from 0% to 25.1% for the MCI group. The improvement in the AD group ranged between 0% and 44.0%. CONCLUSION: The results reflect the cognitive deterioration of patients during the disease progression. Nevertheless, improvements in diagnostic groups could be detected. The significantly positive changes might be due to practice effects, also a lack of motivation or attention in the first test could have yielded “improvement” in the retest.
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spelling pubmed-85008702021-10-19 Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology Rosas, Anna Garcia Stögmann, Elisabeth Lehrner, Johann Wien Klin Wochenschr Short Report OBJECTIVE: The development of Alzheimer’s disease (AD) can be assessed using the neuropsychological test battery Vienna (NTBV). The objective of this study was to investigate whether the NTBV test scores of a diagnostic group have changed significantly over time and whether this change is due to disease progression. METHODS: In this study 358 patients referred to a memory outpatient clinic because of cognitive deterioration were analyzed. The same patients were surveyed in a follow-up assessment after a mean interval of 25.96 months to examine cognitive performance and disease progression. Patients were divided into the subgroups healthy controls (HC), subjective cognitive decline (SCD), mild cognitive impairment (MCI) and AD on the basis of the test results. Reliable change index methodology was used to assess improvement or deterioration in test scores in diagnostic groups compared to HC. RESULTS: Deterioration in the SCD group ranged from 0% to 18.8%. The MCI group showed declines between 1.6% and 29.1%. Patients who developed AD deteriorated between 0% and 54.2%. Improvements ranged from 0% to 73.4% in the SCD group and from 0% to 25.1% for the MCI group. The improvement in the AD group ranged between 0% and 44.0%. CONCLUSION: The results reflect the cognitive deterioration of patients during the disease progression. Nevertheless, improvements in diagnostic groups could be detected. The significantly positive changes might be due to practice effects, also a lack of motivation or attention in the first test could have yielded “improvement” in the retest. Springer Vienna 2020-10-23 2021 /pmc/articles/PMC8500870/ /pubmed/33095320 http://dx.doi.org/10.1007/s00508-020-01755-1 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Report
Rosas, Anna Garcia
Stögmann, Elisabeth
Lehrner, Johann
Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title_full Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title_fullStr Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title_full_unstemmed Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title_short Individual cognitive changes in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease using the reliable change index methodology
title_sort individual cognitive changes in subjective cognitive decline, mild cognitive impairment and alzheimer’s disease using the reliable change index methodology
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500870/
https://www.ncbi.nlm.nih.gov/pubmed/33095320
http://dx.doi.org/10.1007/s00508-020-01755-1
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