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Brain volumes in adults with congenital heart disease correlate with executive function abilities

Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls...

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Autores principales: Naef, Nadja, Schlosser, Ladina, Brugger, Peter, Greutmann, Matthias, Oxenius, Angela, Wehrle, Flavia, Kottke, Raimund, Latal, Beatrice, O’Gorman, Ruth Tuura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500877/
https://www.ncbi.nlm.nih.gov/pubmed/33515180
http://dx.doi.org/10.1007/s11682-020-00424-1
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author Naef, Nadja
Schlosser, Ladina
Brugger, Peter
Greutmann, Matthias
Oxenius, Angela
Wehrle, Flavia
Kottke, Raimund
Latal, Beatrice
O’Gorman, Ruth Tuura
author_facet Naef, Nadja
Schlosser, Ladina
Brugger, Peter
Greutmann, Matthias
Oxenius, Angela
Wehrle, Flavia
Kottke, Raimund
Latal, Beatrice
O’Gorman, Ruth Tuura
author_sort Naef, Nadja
collection PubMed
description Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 years underwent brain magnetic resonance imaging and cognitive testing, assessed with an intelligence quotient and executive function global score. Associations between brain volumes and cognitive function were calculated using linear models. Cognitive function in patients was within the normal range (intelligence quotient: 97.74 (10.76)). Total brain volume was significantly smaller in patients compared to controls (1067.26 (113.53) vs 1113.04 (97.88) cm(3), P < 0.01), irrespective of cardiac factors (heart defect complexity, cyanosis, cardiopulmonary bypass: all P > 0.4). After adjusting for total brain volume, only corpus callosum volume remained significantly smaller (P = 0.03). Smaller total brain volume was associated with poorer overall executive functioning (P = 0.02) and inhibition (P < 0.01), in both patients and controls. The association between total brain volume and overall executive functioning was moderated by parental socioeconomic status (lower socioeconomic status was associated with a stronger association between brain volume and EF; interaction P = 0.03). In adults with congenital heart disease, despite normal intelligence quotient, brain volume alterations persist into adulthood and are related to executive functioning, in particular inhibitory control. Adults coming from low socioeconomic background and with altered brain volumes are especially vulnerable and should thus be followed-up during adulthood to ensure optimal social and educational support. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-020-00424-1.
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spelling pubmed-85008772021-10-19 Brain volumes in adults with congenital heart disease correlate with executive function abilities Naef, Nadja Schlosser, Ladina Brugger, Peter Greutmann, Matthias Oxenius, Angela Wehrle, Flavia Kottke, Raimund Latal, Beatrice O’Gorman, Ruth Tuura Brain Imaging Behav Original Research Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 years underwent brain magnetic resonance imaging and cognitive testing, assessed with an intelligence quotient and executive function global score. Associations between brain volumes and cognitive function were calculated using linear models. Cognitive function in patients was within the normal range (intelligence quotient: 97.74 (10.76)). Total brain volume was significantly smaller in patients compared to controls (1067.26 (113.53) vs 1113.04 (97.88) cm(3), P < 0.01), irrespective of cardiac factors (heart defect complexity, cyanosis, cardiopulmonary bypass: all P > 0.4). After adjusting for total brain volume, only corpus callosum volume remained significantly smaller (P = 0.03). Smaller total brain volume was associated with poorer overall executive functioning (P = 0.02) and inhibition (P < 0.01), in both patients and controls. The association between total brain volume and overall executive functioning was moderated by parental socioeconomic status (lower socioeconomic status was associated with a stronger association between brain volume and EF; interaction P = 0.03). In adults with congenital heart disease, despite normal intelligence quotient, brain volume alterations persist into adulthood and are related to executive functioning, in particular inhibitory control. Adults coming from low socioeconomic background and with altered brain volumes are especially vulnerable and should thus be followed-up during adulthood to ensure optimal social and educational support. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-020-00424-1. Springer US 2021-01-30 2021 /pmc/articles/PMC8500877/ /pubmed/33515180 http://dx.doi.org/10.1007/s11682-020-00424-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Naef, Nadja
Schlosser, Ladina
Brugger, Peter
Greutmann, Matthias
Oxenius, Angela
Wehrle, Flavia
Kottke, Raimund
Latal, Beatrice
O’Gorman, Ruth Tuura
Brain volumes in adults with congenital heart disease correlate with executive function abilities
title Brain volumes in adults with congenital heart disease correlate with executive function abilities
title_full Brain volumes in adults with congenital heart disease correlate with executive function abilities
title_fullStr Brain volumes in adults with congenital heart disease correlate with executive function abilities
title_full_unstemmed Brain volumes in adults with congenital heart disease correlate with executive function abilities
title_short Brain volumes in adults with congenital heart disease correlate with executive function abilities
title_sort brain volumes in adults with congenital heart disease correlate with executive function abilities
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500877/
https://www.ncbi.nlm.nih.gov/pubmed/33515180
http://dx.doi.org/10.1007/s11682-020-00424-1
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