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Brain volumes in adults with congenital heart disease correlate with executive function abilities
Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500877/ https://www.ncbi.nlm.nih.gov/pubmed/33515180 http://dx.doi.org/10.1007/s11682-020-00424-1 |
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author | Naef, Nadja Schlosser, Ladina Brugger, Peter Greutmann, Matthias Oxenius, Angela Wehrle, Flavia Kottke, Raimund Latal, Beatrice O’Gorman, Ruth Tuura |
author_facet | Naef, Nadja Schlosser, Ladina Brugger, Peter Greutmann, Matthias Oxenius, Angela Wehrle, Flavia Kottke, Raimund Latal, Beatrice O’Gorman, Ruth Tuura |
author_sort | Naef, Nadja |
collection | PubMed |
description | Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 years underwent brain magnetic resonance imaging and cognitive testing, assessed with an intelligence quotient and executive function global score. Associations between brain volumes and cognitive function were calculated using linear models. Cognitive function in patients was within the normal range (intelligence quotient: 97.74 (10.76)). Total brain volume was significantly smaller in patients compared to controls (1067.26 (113.53) vs 1113.04 (97.88) cm(3), P < 0.01), irrespective of cardiac factors (heart defect complexity, cyanosis, cardiopulmonary bypass: all P > 0.4). After adjusting for total brain volume, only corpus callosum volume remained significantly smaller (P = 0.03). Smaller total brain volume was associated with poorer overall executive functioning (P = 0.02) and inhibition (P < 0.01), in both patients and controls. The association between total brain volume and overall executive functioning was moderated by parental socioeconomic status (lower socioeconomic status was associated with a stronger association between brain volume and EF; interaction P = 0.03). In adults with congenital heart disease, despite normal intelligence quotient, brain volume alterations persist into adulthood and are related to executive functioning, in particular inhibitory control. Adults coming from low socioeconomic background and with altered brain volumes are especially vulnerable and should thus be followed-up during adulthood to ensure optimal social and educational support. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-020-00424-1. |
format | Online Article Text |
id | pubmed-8500877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-85008772021-10-19 Brain volumes in adults with congenital heart disease correlate with executive function abilities Naef, Nadja Schlosser, Ladina Brugger, Peter Greutmann, Matthias Oxenius, Angela Wehrle, Flavia Kottke, Raimund Latal, Beatrice O’Gorman, Ruth Tuura Brain Imaging Behav Original Research Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 years underwent brain magnetic resonance imaging and cognitive testing, assessed with an intelligence quotient and executive function global score. Associations between brain volumes and cognitive function were calculated using linear models. Cognitive function in patients was within the normal range (intelligence quotient: 97.74 (10.76)). Total brain volume was significantly smaller in patients compared to controls (1067.26 (113.53) vs 1113.04 (97.88) cm(3), P < 0.01), irrespective of cardiac factors (heart defect complexity, cyanosis, cardiopulmonary bypass: all P > 0.4). After adjusting for total brain volume, only corpus callosum volume remained significantly smaller (P = 0.03). Smaller total brain volume was associated with poorer overall executive functioning (P = 0.02) and inhibition (P < 0.01), in both patients and controls. The association between total brain volume and overall executive functioning was moderated by parental socioeconomic status (lower socioeconomic status was associated with a stronger association between brain volume and EF; interaction P = 0.03). In adults with congenital heart disease, despite normal intelligence quotient, brain volume alterations persist into adulthood and are related to executive functioning, in particular inhibitory control. Adults coming from low socioeconomic background and with altered brain volumes are especially vulnerable and should thus be followed-up during adulthood to ensure optimal social and educational support. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-020-00424-1. Springer US 2021-01-30 2021 /pmc/articles/PMC8500877/ /pubmed/33515180 http://dx.doi.org/10.1007/s11682-020-00424-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Naef, Nadja Schlosser, Ladina Brugger, Peter Greutmann, Matthias Oxenius, Angela Wehrle, Flavia Kottke, Raimund Latal, Beatrice O’Gorman, Ruth Tuura Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title | Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title_full | Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title_fullStr | Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title_full_unstemmed | Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title_short | Brain volumes in adults with congenital heart disease correlate with executive function abilities |
title_sort | brain volumes in adults with congenital heart disease correlate with executive function abilities |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500877/ https://www.ncbi.nlm.nih.gov/pubmed/33515180 http://dx.doi.org/10.1007/s11682-020-00424-1 |
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