OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

OTULIN is a deubiquitinase that specifically cleaves linear ubiquitin chains. Here we demonstrate that the ablation of Otulin selectively in keratinocytes causes inflammatory skin lesions that develop into verrucous carcinomas. Genetic deletion of Tnfr1, knockin expression of kinase-inactive Ripk1 o...

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Detalles Bibliográficos
Autores principales: Hoste, Esther, Lecomte, Kim, Annusver, Karl, Vandamme, Niels, Roels, Jana, Maschalidi, Sophia, Verboom, Lien, Vikkula, Hanna-Kaisa, Sze, Mozes, Van Hove, Lisette, Verstaen, Kevin, Martens, Arne, Hochepied, Tino, Saeys, Yvan, Ravichandran, Kodi, Kasper, Maria, van Loo, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501048/
https://www.ncbi.nlm.nih.gov/pubmed/34625556
http://dx.doi.org/10.1038/s41467-021-25944-2

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