CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling

Prediabetic myocardium, induced by fructose-rich diet (FRD), is prone to increased sarcoplasmic reticulum (SR)-Ca(2+) leak and arrhythmias due to increased activity of the Ca(2+)/calmodulin protein kinase II (CaMKII). However, little is known about the role of SR-mitochondria microdomains, mitochond...

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Detalles Bibliográficos
Autores principales: Federico, Marilen, Zavala, Maite, Vico, Tamara, López, Sofía, Portiansky, Enrique, Alvarez, Silvia, Abrille, Maria Celeste Villa, Palomeque, Julieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501049/
https://www.ncbi.nlm.nih.gov/pubmed/34625584
http://dx.doi.org/10.1038/s41598-021-99118-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501049/
https://www.ncbi.nlm.nih.gov/pubmed/34625584
http://dx.doi.org/10.1038/s41598-021-99118-x

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