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CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling
Prediabetic myocardium, induced by fructose-rich diet (FRD), is prone to increased sarcoplasmic reticulum (SR)-Ca(2+) leak and arrhythmias due to increased activity of the Ca(2+)/calmodulin protein kinase II (CaMKII). However, little is known about the role of SR-mitochondria microdomains, mitochond...
Autores principales: | Federico, Marilen, Zavala, Maite, Vico, Tamara, López, Sofía, Portiansky, Enrique, Alvarez, Silvia, Abrille, Maria Celeste Villa, Palomeque, Julieta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501049/ https://www.ncbi.nlm.nih.gov/pubmed/34625584 http://dx.doi.org/10.1038/s41598-021-99118-x |
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