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Human cell based directed evolution of adenine base editors with improved efficiency

Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at certain sites remains a major bottleneck that precludes efficacious applications. Here, to address it, we develop a directional screening syste...

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Detalles Bibliográficos
Autores principales:	Fu, Junhao, Li, Qing, Liu, Xiaoyu, Tu, Tianxiang, Lv, Xiujuan, Yin, Xidi, Lv, Jineng, Song, Zongming, Qu, Jia, Zhang, Jinwei, Li, Jinsong, Gu, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501064/ https://www.ncbi.nlm.nih.gov/pubmed/34625552 http://dx.doi.org/10.1038/s41467-021-26211-0

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