Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor membranes. Loss-of-function mutations cause Stargardt disease (STGD1), a macular dystrophy associated with severe vision loss. T...

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Detalles Bibliográficos
Autores principales: Scortecci, Jessica Fernandes, Molday, Laurie L., Curtis, Susan B., Garces, Fabian A., Panwar, Pankaj, Van Petegem, Filip, Molday, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501128/
https://www.ncbi.nlm.nih.gov/pubmed/34625547
http://dx.doi.org/10.1038/s41467-021-26161-7

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