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Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). Vaccine development approaches consist of viral vector vaccines, DNA vaccine, RNA vaccine, live attenuated virus, and recombinant proteins, which elicit a specific immune response. The use of nanoparticles displayi...

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Autores principales: Sa-nguanmoo, Nawamin, Namdee, Katawut, Khongkow, Mattaka, Ruktanonchai, Uracha, Zhao, YongXiang, Liang, Xing-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tsinghua University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501370/
https://www.ncbi.nlm.nih.gov/pubmed/34659650
http://dx.doi.org/10.1007/s12274-021-3832-y
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author Sa-nguanmoo, Nawamin
Namdee, Katawut
Khongkow, Mattaka
Ruktanonchai, Uracha
Zhao, YongXiang
Liang, Xing-Jie
author_facet Sa-nguanmoo, Nawamin
Namdee, Katawut
Khongkow, Mattaka
Ruktanonchai, Uracha
Zhao, YongXiang
Liang, Xing-Jie
author_sort Sa-nguanmoo, Nawamin
collection PubMed
description Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). Vaccine development approaches consist of viral vector vaccines, DNA vaccine, RNA vaccine, live attenuated virus, and recombinant proteins, which elicit a specific immune response. The use of nanoparticles displaying antigen is one of the alternative approaches to conventional vaccines. This is due to the fact that nano-based vaccines are stable, able to target, form images, and offer an opportunity to enhance the immune responses. The diameters of ultrafine nanoparticles are in the range of 1–100 nm. The application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable features. To be successful, nanomaterials must be uptaken into the cell, especially into the target and able to modulate cellular functions at the subcellular levels. The advantages of nano-based vaccines are the ability to protect a cargo such as RNA, DNA, protein, or synthesis substance and have enhanced stability in a broad range of pH, ambient temperatures, and humidity for long-term storage. Moreover, nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting cells. In this review, we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver antigens. The discussion about their safe, effective, and affordable vaccines to immunize against COVID-19 will be highlighted. [Image: see text]
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spelling pubmed-85013702021-10-12 Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform Sa-nguanmoo, Nawamin Namdee, Katawut Khongkow, Mattaka Ruktanonchai, Uracha Zhao, YongXiang Liang, Xing-Jie Nano Res Review Article Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). Vaccine development approaches consist of viral vector vaccines, DNA vaccine, RNA vaccine, live attenuated virus, and recombinant proteins, which elicit a specific immune response. The use of nanoparticles displaying antigen is one of the alternative approaches to conventional vaccines. This is due to the fact that nano-based vaccines are stable, able to target, form images, and offer an opportunity to enhance the immune responses. The diameters of ultrafine nanoparticles are in the range of 1–100 nm. The application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable features. To be successful, nanomaterials must be uptaken into the cell, especially into the target and able to modulate cellular functions at the subcellular levels. The advantages of nano-based vaccines are the ability to protect a cargo such as RNA, DNA, protein, or synthesis substance and have enhanced stability in a broad range of pH, ambient temperatures, and humidity for long-term storage. Moreover, nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting cells. In this review, we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver antigens. The discussion about their safe, effective, and affordable vaccines to immunize against COVID-19 will be highlighted. [Image: see text] Tsinghua University Press 2021-10-09 2022 /pmc/articles/PMC8501370/ /pubmed/34659650 http://dx.doi.org/10.1007/s12274-021-3832-y Text en © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Sa-nguanmoo, Nawamin
Namdee, Katawut
Khongkow, Mattaka
Ruktanonchai, Uracha
Zhao, YongXiang
Liang, Xing-Jie
Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title_full Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title_fullStr Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title_full_unstemmed Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title_short Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
title_sort review: development of sars-cov-2 immuno-enhanced covid-19 vaccines with nano-platform
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501370/
https://www.ncbi.nlm.nih.gov/pubmed/34659650
http://dx.doi.org/10.1007/s12274-021-3832-y
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