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Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)

Cerebral visual impairment (CVI) is associated with a wide range of visual perceptual deficits including global motion processing. However, the underlying neurophysiological basis for these impairments remain poorly understood. We investigated global motion processing abilities in individuals with C...

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Autores principales: Pamir, Zahide, Bauer, Corinna M., Bailin, Emma S., Bex, Peter J., Somers, David C., Merabet, Lotfi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501506/
https://www.ncbi.nlm.nih.gov/pubmed/34628303
http://dx.doi.org/10.1016/j.nicl.2021.102821
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author Pamir, Zahide
Bauer, Corinna M.
Bailin, Emma S.
Bex, Peter J.
Somers, David C.
Merabet, Lotfi B.
author_facet Pamir, Zahide
Bauer, Corinna M.
Bailin, Emma S.
Bex, Peter J.
Somers, David C.
Merabet, Lotfi B.
author_sort Pamir, Zahide
collection PubMed
description Cerebral visual impairment (CVI) is associated with a wide range of visual perceptual deficits including global motion processing. However, the underlying neurophysiological basis for these impairments remain poorly understood. We investigated global motion processing abilities in individuals with CVI compared to neurotypical controls using a combined behavioral and multi-modal neuroimaging approach. We found that CVI participants had a significantly higher mean motion coherence threshold (determined using a random dot kinematogram pattern simulating optic flow motion) compared to controls. Using functional magnetic resonance imaging (fMRI), we investigated activation response profiles in functionally defined early (i.e. primary visual cortex; area V1) and higher order (i.e. middle temporal cortex; area hMT+) stages of motion processing. In area V1, responses to increasing motion coherence were similar in both groups. However, in the CVI group, activation in area hMT+ was significantly reduced compared to controls, and consistent with a surround facilitation (rather than suppression) response profile. White matter tract reconstruction obtained from high angular resolution diffusion imaging (HARDI) revealed evidence of increased mean, axial, and radial diffusivities within cortico-cortical (i.e. V1-hMT+), but not thalamo-hMT+ connections. Overall, our results suggest that global motion processing deficits in CVI may be associated with impaired signal integration and segregation mechanisms, as well as white matter integrity at the level of area hMT+.
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spelling pubmed-85015062021-10-12 Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI) Pamir, Zahide Bauer, Corinna M. Bailin, Emma S. Bex, Peter J. Somers, David C. Merabet, Lotfi B. Neuroimage Clin Regular Article Cerebral visual impairment (CVI) is associated with a wide range of visual perceptual deficits including global motion processing. However, the underlying neurophysiological basis for these impairments remain poorly understood. We investigated global motion processing abilities in individuals with CVI compared to neurotypical controls using a combined behavioral and multi-modal neuroimaging approach. We found that CVI participants had a significantly higher mean motion coherence threshold (determined using a random dot kinematogram pattern simulating optic flow motion) compared to controls. Using functional magnetic resonance imaging (fMRI), we investigated activation response profiles in functionally defined early (i.e. primary visual cortex; area V1) and higher order (i.e. middle temporal cortex; area hMT+) stages of motion processing. In area V1, responses to increasing motion coherence were similar in both groups. However, in the CVI group, activation in area hMT+ was significantly reduced compared to controls, and consistent with a surround facilitation (rather than suppression) response profile. White matter tract reconstruction obtained from high angular resolution diffusion imaging (HARDI) revealed evidence of increased mean, axial, and radial diffusivities within cortico-cortical (i.e. V1-hMT+), but not thalamo-hMT+ connections. Overall, our results suggest that global motion processing deficits in CVI may be associated with impaired signal integration and segregation mechanisms, as well as white matter integrity at the level of area hMT+. Elsevier 2021-09-21 /pmc/articles/PMC8501506/ /pubmed/34628303 http://dx.doi.org/10.1016/j.nicl.2021.102821 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Pamir, Zahide
Bauer, Corinna M.
Bailin, Emma S.
Bex, Peter J.
Somers, David C.
Merabet, Lotfi B.
Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title_full Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title_fullStr Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title_full_unstemmed Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title_short Neural correlates associated with impaired global motion perception in cerebral visual impairment (CVI)
title_sort neural correlates associated with impaired global motion perception in cerebral visual impairment (cvi)
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501506/
https://www.ncbi.nlm.nih.gov/pubmed/34628303
http://dx.doi.org/10.1016/j.nicl.2021.102821
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