Identification and characterization of SARS-CoV-2 clusters in the EU/EEA in the first pandemic wave: additional elements to trace the route of the virus

A high-quality dataset of 3289 complete SARS-CoV-2 genomes collected in Europe and European Economic Area (EAA) in the early phase of the first wave of the pandemic was analyzed. Among all single nucleotide mutations, 41 had a frequency ≥ 1%, and the phylogenetic analysis showed at least 6 clusters...

Descripción completa

Detalles Bibliográficos
Autores principales: Faggioni, Giovanni, Stefanelli, Paola, Giordani, Francesco, Fillo, Silvia, Anselmo, Anna, Vera Fain, Vanessa, Fortunato, Antonella, Petralito, Giancarlo, Molinari, Filippo, Lo Presti, Alessandra, Di Martino, Angela, Palomba, Stefano, De Santis, Riccardo, Rezza, Giovanni, Lista, Florigio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501518/
https://www.ncbi.nlm.nih.gov/pubmed/34637920
http://dx.doi.org/10.1016/j.meegid.2021.105108
Descripción
Sumario:A high-quality dataset of 3289 complete SARS-CoV-2 genomes collected in Europe and European Economic Area (EAA) in the early phase of the first wave of the pandemic was analyzed. Among all single nucleotide mutations, 41 had a frequency ≥ 1%, and the phylogenetic analysis showed at least 6 clusters with a specific mutational profile. These clusters were differentially distributed in the EU/EEA, showing a statistically significant association with the geographic origin. The analysis highlighted that the mutations C(14408)T and C(14805)T played an important role in clusters selection and further virus spread. Moreover, the molecular analysis suggests that the SARS-CoV-2 strain responsible for the first Italian confirmed COVID-19 case was already circulating outside the country.

Ejemplares similares