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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

BACKGROUND: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral escape from this promising class of HIV-1 entry inhibitors. RESULTS: HI...

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Detalles Bibliográficos
Autores principales:	Zhang, Shiyu, Holmes, Andrew P., Dick, Alexej, Rashad, Adel A., Enríquez Rodríguez, Lucía, Canziani, Gabriela A., Root, Michael J., Chaiken, Irwin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501640/ https://www.ncbi.nlm.nih.gov/pubmed/34627310 http://dx.doi.org/10.1186/s12977-021-00575-z

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