Multifaced roles of PLAC8 in cancer

The role of PLAC8 in tumorigenesis has been gradually elucidated with the development of research. Although there are common molecular mechanisms that enforce cell growth, the impact of PLAC8 is varied and can, in some instances, have opposite effects on tumorigenesis. To systematically understand t...

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Autores principales: Mao, Misha, Cheng, Yifan, Yang, Jingjing, Chen, Yongxia, Xu, Ling, Zhang, Xun, Li, Zhaoqing, Chen, Cong, Ju, Siwei, Zhou, Jichun, Wang, Linbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501656/
https://www.ncbi.nlm.nih.gov/pubmed/34627411
http://dx.doi.org/10.1186/s40364-021-00329-1
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author Mao, Misha
Cheng, Yifan
Yang, Jingjing
Chen, Yongxia
Xu, Ling
Zhang, Xun
Li, Zhaoqing
Chen, Cong
Ju, Siwei
Zhou, Jichun
Wang, Linbo
author_facet Mao, Misha
Cheng, Yifan
Yang, Jingjing
Chen, Yongxia
Xu, Ling
Zhang, Xun
Li, Zhaoqing
Chen, Cong
Ju, Siwei
Zhou, Jichun
Wang, Linbo
author_sort Mao, Misha
collection PubMed
description The role of PLAC8 in tumorigenesis has been gradually elucidated with the development of research. Although there are common molecular mechanisms that enforce cell growth, the impact of PLAC8 is varied and can, in some instances, have opposite effects on tumorigenesis. To systematically understand the role of PLAC8 in tumors, the molecular functions of PLAC8 in cancer will be discussed by focusing on how PLAC8 impacts tumorigenesis when it arises within tumor cells and how these roles can change in different stages of cancer progression with the ultimate goal of suppressing PLAC8-relevant cancer behavior and related pathologies. In addition, we highlight the diversity of PLAC8 in different tumors and its functional output beyond cancer cell growth. The comprehension of PLAC8’s molecular function might provide new target and lead to the development of novel anticancer therapies.
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spelling pubmed-85016562021-10-20 Multifaced roles of PLAC8 in cancer Mao, Misha Cheng, Yifan Yang, Jingjing Chen, Yongxia Xu, Ling Zhang, Xun Li, Zhaoqing Chen, Cong Ju, Siwei Zhou, Jichun Wang, Linbo Biomark Res Review The role of PLAC8 in tumorigenesis has been gradually elucidated with the development of research. Although there are common molecular mechanisms that enforce cell growth, the impact of PLAC8 is varied and can, in some instances, have opposite effects on tumorigenesis. To systematically understand the role of PLAC8 in tumors, the molecular functions of PLAC8 in cancer will be discussed by focusing on how PLAC8 impacts tumorigenesis when it arises within tumor cells and how these roles can change in different stages of cancer progression with the ultimate goal of suppressing PLAC8-relevant cancer behavior and related pathologies. In addition, we highlight the diversity of PLAC8 in different tumors and its functional output beyond cancer cell growth. The comprehension of PLAC8’s molecular function might provide new target and lead to the development of novel anticancer therapies. BioMed Central 2021-10-09 /pmc/articles/PMC8501656/ /pubmed/34627411 http://dx.doi.org/10.1186/s40364-021-00329-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mao, Misha
Cheng, Yifan
Yang, Jingjing
Chen, Yongxia
Xu, Ling
Zhang, Xun
Li, Zhaoqing
Chen, Cong
Ju, Siwei
Zhou, Jichun
Wang, Linbo
Multifaced roles of PLAC8 in cancer
title Multifaced roles of PLAC8 in cancer
title_full Multifaced roles of PLAC8 in cancer
title_fullStr Multifaced roles of PLAC8 in cancer
title_full_unstemmed Multifaced roles of PLAC8 in cancer
title_short Multifaced roles of PLAC8 in cancer
title_sort multifaced roles of plac8 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501656/
https://www.ncbi.nlm.nih.gov/pubmed/34627411
http://dx.doi.org/10.1186/s40364-021-00329-1
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