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Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications

Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars aft...

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Autores principales: Shpilsky, Gabriella F., Takahashi, Hiroyuki, Aristarkhova, Anna, Weil, Michele, Ng, Nathan, Nelson, Kacie J., Lee, Amanda, Zheng, Hui, Kühtreiber, Willem M., Faustman, Denise L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501688/
https://www.ncbi.nlm.nih.gov/pubmed/34646988
http://dx.doi.org/10.1016/j.isci.2021.103150
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author Shpilsky, Gabriella F.
Takahashi, Hiroyuki
Aristarkhova, Anna
Weil, Michele
Ng, Nathan
Nelson, Kacie J.
Lee, Amanda
Zheng, Hui
Kühtreiber, Willem M.
Faustman, Denise L.
author_facet Shpilsky, Gabriella F.
Takahashi, Hiroyuki
Aristarkhova, Anna
Weil, Michele
Ng, Nathan
Nelson, Kacie J.
Lee, Amanda
Zheng, Hui
Kühtreiber, Willem M.
Faustman, Denise L.
author_sort Shpilsky, Gabriella F.
collection PubMed
description Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars after multidose BCG. Using a glucose transport assay, monocytes from T1D subjects showed a large stimulation index with BCG exposures; LADA subjects showed minimal BCG-induced sugar responsiveness. Monocytes from T1D, type 2 diabetes (T2D), and non-diabetic controls (NDC) were all responsive in vitro to BCG by augmented sugar utilization. Adults with prior neonatal BCG vaccination show accelerated glucose transport decades later. Finally, in vivo experiments with the NOD mouse (a T1D model) and obese db/db mice (a T2D model) confirm BCG's blood-sugar-lowering and accelerated glucose metabolism with sufficient dosing. Our results suggest that BCG's benefits for glucose metabolism may be broadly applicable to T1D and T2D, but less to LADA.
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spelling pubmed-85016882021-10-12 Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications Shpilsky, Gabriella F. Takahashi, Hiroyuki Aristarkhova, Anna Weil, Michele Ng, Nathan Nelson, Kacie J. Lee, Amanda Zheng, Hui Kühtreiber, Willem M. Faustman, Denise L. iScience Article Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars after multidose BCG. Using a glucose transport assay, monocytes from T1D subjects showed a large stimulation index with BCG exposures; LADA subjects showed minimal BCG-induced sugar responsiveness. Monocytes from T1D, type 2 diabetes (T2D), and non-diabetic controls (NDC) were all responsive in vitro to BCG by augmented sugar utilization. Adults with prior neonatal BCG vaccination show accelerated glucose transport decades later. Finally, in vivo experiments with the NOD mouse (a T1D model) and obese db/db mice (a T2D model) confirm BCG's blood-sugar-lowering and accelerated glucose metabolism with sufficient dosing. Our results suggest that BCG's benefits for glucose metabolism may be broadly applicable to T1D and T2D, but less to LADA. Elsevier 2021-09-21 /pmc/articles/PMC8501688/ /pubmed/34646988 http://dx.doi.org/10.1016/j.isci.2021.103150 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shpilsky, Gabriella F.
Takahashi, Hiroyuki
Aristarkhova, Anna
Weil, Michele
Ng, Nathan
Nelson, Kacie J.
Lee, Amanda
Zheng, Hui
Kühtreiber, Willem M.
Faustman, Denise L.
Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_full Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_fullStr Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_full_unstemmed Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_short Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_sort bacillus calmette-guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501688/
https://www.ncbi.nlm.nih.gov/pubmed/34646988
http://dx.doi.org/10.1016/j.isci.2021.103150
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