Cargando…

Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival

Integrin alpha 2 (ITGA2) promotes cancer metastasis through selective adhesion to ECM proteins; however, the specific contribution of integrin glycosylation remains uncertain. We provide evidence that ITGA2 is a highly glycosylated transmembrane protein expressed in ovarian cancer tissue and cell li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yen-Lin, Liang, Ching-Yeu, Labitzky, Vera, Ritz, Danilo, Oliveira, Tiago, Cumin, Cécile, Estermann, Manuela, Lange, Tobias, Everest-Dass, Arun V., Jacob, Francis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501769/ https://www.ncbi.nlm.nih.gov/pubmed/34646995 http://dx.doi.org/10.1016/j.isci.2021.103168

Ejemplares similares

Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
por: Huang, Yen-Lin, et al.
Publicado: (2020)

Deciphering the Importance of Glycosphingolipids on Cellular and Molecular Mechanisms Associated with Epithelial-to-Mesenchymal Transition in Cancer
por: Cumin, Cécile, et al.
Publicado: (2021)

Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
por: Estermann, Manuela, et al.
Publicado: (2020)

Differential glycosylation of collagen modulates lung cancer stem cell subsets through β1 integrin‐mediated interactions
por: Gardelli, Cecilia, et al.
Publicado: (2020)

The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments
por: Hoffmann, Bertin, et al.
Publicado: (2020)

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
por: Kadler, Karl E, et al.
Publicado: (2008)

Roles of Integrin α6β4 Glycosylation in Cancer
por: Kariya, Yoshinobu, et al.
Publicado: (2017)

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
por: Stanczak, Michal A., et al.
Publicado: (2022)

The exploitation of human glycans by Group A Streptococcus
por: Indraratna, Anuk D, et al.
Publicado: (2022)

N-Glycosylation of ß4 Integrin Controls the Adhesion and Motility of Keratinocytes
por: Kariya, Yoshinobu, et al.
Publicado: (2011)

A General Protein O-Glycosylation Gene Cluster Encodes the Species-Specific Glycan of the Oral Pathogen Tannerella forsythia: O-Glycan Biosynthesis and Immunological Implications
por: Tomek, Markus B., et al.
Publicado: (2018)

Tissue glycomics distinguish tumour sites in women with advanced serous adenocarcinoma
por: Anugraham, Merrina, et al.
Publicado: (2017)

The importance of N-glycosylation on β(3) integrin ligand binding and conformational regulation
por: Cai, Xiulei, et al.
Publicado: (2017)

Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis
por: Bourgot, Isabelle, et al.
Publicado: (2020)

The Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms
por: Prieto, Tabatha Gutierrez, et al.
Publicado: (2021)

Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen-degrading enzyme cathepsin K activity
por: Date, Kimie, et al.
Publicado: (2021)

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation
por: Xu, Huifang, et al.
Publicado: (2012)

Trends in oligomannosylation and α1,2-mannosidase expression in human cancers
por: Chatterjee, Sayantani, et al.
Publicado: (2021)

Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness
por: Sealy, Joshua E., et al.
Publicado: (2020)

Integrin α11β1 is a receptor for collagen XIII
por: Koivunen, Jarkko, et al.
Publicado: (2020)

Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin
por: Hunter, Emma J., et al.
Publicado: (2021)

The crucial role of collagen-binding integrins in maintaining the mechanical properties of human scleral fibroblasts-seeded collagen matrix
por: Hu, Shoulong, et al.
Publicado: (2011)

The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen
por: Malcor, Jean-Daniel, et al.
Publicado: (2016)

Reduced background autofluorescence for cell imaging using nanodiamonds and lanthanide chelates
por: Cordina, Nicole M., et al.
Publicado: (2018)

Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels
por: Reyhani, Vahid, et al.
Publicado: (2014)

Rose Bengal Crosslinking to Stabilize Collagen Sheets and Generate Modulated Collagen Laminates
por: Eckes, Stefanie, et al.
Publicado: (2020)

Heterogeneity in 2,6-Linked Sialic Acids Potentiates Invasion of Breast Cancer Epithelia
por: Pally, Dharma, et al.
Publicado: (2021)

Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions
por: Starzonek, Sarah, et al.
Publicado: (2020)

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4
por: Hang, Qinglei, et al.
Publicado: (2016)

Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer
por: Jin, Di, et al.
Publicado: (2020)

The Surface Charge of Polymer-Coated Upconversion Nanoparticles Determines Protein Corona Properties and Cell Recognition in Serum Solutions
por: Liang, Liuen, et al.
Publicado: (2022)

Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes
Publicado: (1983)

BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis
por: Lee, M-R, et al.
Publicado: (2014)

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen
Publicado: (1990)

Development of antithrombotic nanoconjugate blocking integrin α2β1-collagen interactions
por: Zhang, Chao, et al.
Publicado: (2016)

Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding
por: Yigit, Sezin, et al.
Publicado: (2016)

Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions
por: Pugh, Nicholas, et al.
Publicado: (2017)

α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes
por: Jayadev, Ranjay, et al.
Publicado: (2019)

Unique charge-dependent constraint on collagen recognition by integrin α10β1
por: Hamaia, Samir W., et al.
Publicado: (2017)

165. Nanoparticulate Mineralized Collagen Scaffolds Activate The Integrin B1 Signaling Pathway
por: LaGuardia, Jonnby S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7b95um18ksmkd6vp7hjls8iufa