Structural basis for isoform-specific inhibition of human CTPS1

Cytidine triphosphate synthase 1 (CTPS1) is necessary for an effective immune response, as revealed by severe immunodeficiency in CTPS1-deficient individuals [E. Martin et al.], [Nature] [510], [288–292] ([2014]). CTPS1 expression is up-regulated in activated lymphocytes to expand CTP pools [E. Mart...

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Detalles Bibliográficos
Autores principales: Lynch, Eric M., DiMattia, Michael A., Albanese, Steven, van Zundert, Gydo C. P., Hansen, Jesse M., Quispe, Joel D., Kennedy, Madison A., Verras, Andreas, Borrelli, Kenneth, Toms, Angela V., Kaila, Neelu, Kreutter, Kevin D., McElwee, Joshua J., Kollman, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501788/
https://www.ncbi.nlm.nih.gov/pubmed/34583994
http://dx.doi.org/10.1073/pnas.2107968118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501788/
https://www.ncbi.nlm.nih.gov/pubmed/34583994
http://dx.doi.org/10.1073/pnas.2107968118

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